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Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome)
Test number: 8878
Gene Name: EFNB3
Short Name: CMM1
Price: £ 48.00 (including VAT)
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update |
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test name amended to Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome) - Old name BHS1
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Description |
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Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome) is an inherited disorder affecting the Weimaraner breed. The disease is characterized by the simultaneous movement or 'bunny hopping' of the hind legs. Other signs include weakness and lack of coordination in the rear, while the front limbs remain coordinated and strong. Bunny hopping may occasionally be seen in the front legs. The disease is caused mutation which leads to malformations of the spinal cord during embryonic development.
In mammals, the nerves from one half of the brain control the opposite half of the body. This means that nerves from the left half of the brain innervate the right half of the body and vice versa. For movement control to function correctly, nerve pathways in the spinal cord must only ever run on one side of the body. However, In dogs with CMM1, this strict order is disrupted and nerve pathways in the spinal cord switch sides. As a result, affected dogs cannot control either the left or the right hind leg, and always hop with both legs. Because this gait resembles the hopping of a bunny, the disease is called Bunny Hopping Syndrome. In contrast to Shaking-Puppy-Syndrome in Weimaraner dogs, the gait of CMM1-affected puppies does not improve as they grow based on current knowledge. Consequently, euthanasia is often considered as a result.
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Trait of Inheritance |
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CMM1 has an autosomal recessive trait of inheritancehas an autosomal recessive trait of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CMM1 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CMM1 / CMM1 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Congenital Mirror Movement Disorder 1 (CMM1) (Bunny Hopping Syndrome) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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| See also: |
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