LABOKLIN (UK)| Genetic Diseases | Horses| Occipitoatlantoaxial Malformation (OAAM) *

Occipitoatlantoaxial Malformation (OAAM) *

Test number: 8850

Price: £ 78.00 (including VAT)

Breed

Arabian .

Trait of Inheritance

Autosomal recessive trait of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.
It is very unlikely that the horse will develop Occipitoatlantoaxial Malformation (OAAM) *. The horse will never pass the mutation to its offspring, and therefore it can be bred to any other horse.

Carrier

Genotype: N / [ Heterozygous ]

The horse carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the horse will develop Occipitoatlantoaxial Malformation (OAAM) * but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear horses.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: / [ Homozygous mutant ]

The horse carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The horse is likely to develop Occipitoatlantoaxial Malformation (OAAM) * and will pass the mutant gene to its entire offspring

Description

Occipitoatlantoaxial malformation (OAAM) is a developmental defect which causes compression of the upper cervical cord leading to subsequent neurological damage including incoordination and weakness of the limbs.

Affected individuals exhibit abnormal head and neck carriage with neck extended, reluctance to move the neck, or signs of neck twisting.

Sample Requirements

Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.

Turnaround

4-5 weeks

Price

£ 78.00 (including VAT)