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Vizsla DNA bundle (DM Exon 2 + ECLE + NCCD + Hairlength I + Furnishing)
Test number: 8836
Price: £ 138.00 (including VAT) for all 5 tests
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1 ) Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2) / SOD1
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Breeds
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Airedale Terrier
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Alaskan Malamute
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All Dog Breeds
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American Eskimo
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Bernese Mountain Dog
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Bloodhound
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Borzoi (Russian Wolfhound)
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Boxer
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Cavalier King Charles Spaniel
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Canaan Dog
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Welsh Corgi (Cardigan)
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Chesapeake Bay Retriever
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Cockapoo (English)
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Cockapoo (American)
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Fox Terrier
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French Bull Dog
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German Shepherd
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Glen Of Imaal Terrier ( GIT )
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Golden Retriever
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Goldendoodle
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Pyrenean Mountain Dog (Great Pyrenees)
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Hovawart
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Pumi ( Hungarian Pumi / Pumik )
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Jack Russell Terrier
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Kerry Blue Terrier
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Labradoodle
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Labrador Retriever
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Lakeland Terrier
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Northern Inuit (Tamaskan / British Timber Dog)
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Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
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Pembroke Welsh Corgi
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Poodle
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Pug
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Rhodesian Ridgeback
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Rough Collie
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Soft Coated Wheaten Terrier
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Shetland Sheepdog (Sheltie)
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Smooth Collie
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Utonagan
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Wire Fox Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Chesapeake Bay Retriever, French Bull Dog, German Shepherd, Nova Scotia Duck tolling Retriever ( NSDTR / Toller), Rough Collie, and Smooth Collie.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including German Shepherds, Boxers, Chesapeake Bay Retrievers, Rhodesian Ridgebacks, and both breeds of Welsh Corgis. The disease is chronic and progressive, and resulting in paralysis.
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Clinical Signs |
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Degenerative myelopathy initially affects the back legs and causes muscle weakness and loss, and lack of coordination. These cause a staggering effect that may appear to be arthritis. The dog may drag one or both rear paws when it walks. This dragging can cause the nails of one foot to be worn down. The condition may lead to extensive paralysis of the back legs. As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking. If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy. Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia.
Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive up to three years
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Trait of Inheritance |
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Tow alleles are invloved in Degenerative Myelopathy, A and G, therefore a test result can be A/A, A/G, or G/G.
Mode of inheritance is autosomal recessive with variable penetrance;
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Carrier
Genotype: N / DM (Exon 2) [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Affected
Genotype: DM (Exon 2) / DM (Exon 2) [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog may or may not show signs of the disease
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2 ) Exfoliative Cutaneous Lupus Rrythematosus ( ECLE ) / Lupoid Dermatosis
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Breeds
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German Shorthair Pointer
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Hungarian Vizsla (Magyar Vizsla / Smooth haired)
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Hungarian Wirehaired Vizsla (Vizslak)
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The Disease |
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Exfoliative Cutaneous Lupus Erythematosus (ECLE), which is also known as Lupoid Dermatosis is an inherited monogenic (controlled by one gene) disease that has been observed in the German Shorthaired Pointer and Hungarian Vizsla breeds. Symptoms start in the first year of age and include skin lesions, lameness, scaling, erythema (reddening of the skin), erosions/ulcers, scarring, disfiguration, decreased quality of life, progresses to joint pain, oligospermia (low sperm count) in males which progressed to azoospermia (absence of sperm), irregular heat cycles in females. Dogs with this disease have dramatically shortened life expectancies and are generally humanely euthanized upon diagnosis.
The mode of inheritance is autosomal recessive, which means that the disease occur when the puppy inherits two copies of the mutation, one from each parent. |
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3 ) Neonatal Cortical Cerebellar Abiotrophy (NCCD)
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Breeds
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Beagle
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Hungarian Vizsla (Magyar Vizsla / Smooth haired)
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Hungarian Wirehaired Vizsla (Vizslak)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Beagle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Cerebellar abiotrophy in Beagle is a genetic disease that causes programmed cell-death of Purkinje-cells in the cerebellum. This loss of brain tissue leads to dysfunction of balance and motor funktion.
Affected dogs exhibit symptoms soon after birth or in very early age. These include tremor, ataxia and spastic paralysis.
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Trait of Inheritance |
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Autosomal recessive
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Neonatal Cortical Cerebellar Abiotrophy (NCCD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / NCCD [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Neonatal Cortical Cerebellar Abiotrophy (NCCD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: NCCD / NCCD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Neonatal Cortical Cerebellar Abiotrophy (NCCD) and will pass the mutant gene to its entire offspring
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4 ) Coat (hair) Length I ( Long or Short Hair)
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Breeds
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Alaskan Malamute
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All Dog Breeds
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Border Collie
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Welsh Corgi (Cardigan)
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Collie
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German Shepherd
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Pembroke Welsh Corgi
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Rottweiler
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St. Bernard
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Description |
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One of the most obvious gross morphological differences among dogs of different breeds is the length of their hair. For the majority of registered dog breeds, the breed standard allows only one hair length. However, variable hair lengths are allowed by the standard for some breeds, such as collies, Border collies, dachshunds and St. Bernards. In other breeds, such as Pembroke Welsh Corgis, the occasional appearance of long-haired dogs (also called “fluffies” in this breed) has been a problem for breeders. It has recently been demonstrated in some dog breeds (e.g. Welsh Corgi, Collie, Border Collie, German Shepherd Dog, Miniature long-haired and Smooth Dachshund) that a missense mutation is associated with the hair-length differences among these breeds. Long-haired coat length is inherited a an autosomal recessiv trait, therefore dogs that are carriers of the long hair mutation will appear to be normal (short hair) themselves but will likely pass on the long-hair mutation 50% of the time. Long hair is also know as Fluffy is some breeds.
The DNA test allows to distinguish between 3 possible genotypes:
1. L/L Short Hair having 2 copies of the normal short-hair allele 'L'.
2. L/l Short Hair carrying the long hair mutation - carrier having 1 copy of the normal short-hair allele 'L' and 1 copy of the long-hair mutation 'l'.
3. l/l Long Hair having 2 copies of the long-hair mutation 'l'.
Short Hair (L) is dominant over Long Hair (l)
Please note that this test Coat Length I is valid for all dog breeds, however, in the breeds listed below you should test for this mutation (Coat Length I) and for another mutation (Coat Length II) which is also responsible for Coat Length: Afghan Hound, Akita Inu, Alaskan Malamute, ChowChow, Eurasian, Husky, Prager Rattler and Samoyed
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5 ) Furnishings
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Breeds
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All Dog Breeds
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Barbet (French Water Dog)
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Griffon Bruxellois (Brussels Griffon)
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Chinese Crested
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Dachshund
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German Wirehaired Pointer
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Havana Silk Dog
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Havanese - Bichon Havanese
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Hungarian Vizsla (Magyar Vizsla / Smooth haired)
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Lagotto Romagnolo
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Soft Coated Wheaten Terrier
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Various dog breeds
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Hungarian Wirehaired Vizsla (Vizslak)
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Description |
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Furnishings refer to the longer facial hair around the eyebrows, moustache, and beard commonly seen in many breeds, including the wirehaired breeds. Presence of furnishings is dominant to the unfurnished version of the gene, which depending on breed may also be referred to as satin, or sleek. LABOKLIN offers a test to see if a furnished dog carries the recessive unfurnished trait. This coat variant is called 'improper coat' in portuguese waterdogs. In Hungarian Wirehaired Vizsla (Vizslak) this it is called Wirehair.
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Price
for the above 5 tests
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£ 138.00 (including VAT)
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