Airedale Terrier
,
Alaskan Malamute
,
All Dog Breeds
,
American Eskimo
,
Bernese Mountain Dog
,
Bloodhound
,
Borzoi (Russian Wolfhound)
,
Boxer
,
Cavalier King Charles Spaniel
,
Canaan Dog
,
Welsh Corgi (Cardigan)
,
Chesapeake Bay Retriever
,
Cockapoo (English)
,
Cockapoo (American)
,
Fox Terrier
,
French Bull Dog
,
German Shepherd
,
Glen Of Imaal Terrier ( GIT )
,
Golden Retriever
,
Goldendoodle
,
Pyrenean Mountain Dog (Great Pyrenees)
,
Hovawart
,
Pumi ( Hungarian Pumi / Pumik )
,
Jack Russell Terrier
,
Kerry Blue Terrier
,
Labradoodle
,
Labrador Retriever
,
Lakeland Terrier
,
Northern Inuit (Tamaskan / British Timber Dog)
,
Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
,
Pembroke Welsh Corgi
,
Poodle
,
Pug
,
Rhodesian Ridgeback
,
Rough Collie
,
Soft Coated Wheaten Terrier
,
Shetland Sheepdog (Sheltie)
,
Smooth Collie
,
Utonagan
,
Wire Fox Terrier
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Chesapeake Bay Retriever, French Bull Dog, German Shepherd, Nova Scotia Duck tolling Retriever ( NSDTR / Toller), Rough Collie, and Smooth Collie.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including German Shepherds, Boxers, Chesapeake Bay Retrievers, Rhodesian Ridgebacks, and both breeds of Welsh Corgis. The disease is chronic and progressive, and resulting in paralysis.
Clinical Signs
Degenerative myelopathy initially affects the back legs and causes muscle weakness and loss, and lack of coordination. These cause a staggering effect that may appear to be arthritis. The dog may drag one or both rear paws when it walks. This dragging can cause the nails of one foot to be worn down. The condition may lead to extensive paralysis of the back legs. As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking. If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy. Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia.
Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive up to three years
Trait of Inheritance
Tow alleles are invloved in Degenerative Myelopathy, A and G, therefore a test result can be A/A, A/G, or G/G.
Mode of inheritance is autosomal recessive with variable penetrance;
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog may or may not show signs of the disease
Description
SOD1-Gene
Please note that Exon 2 can be found in all dog breeds, there is another DM mutation in Exon 1 which can only be found in Bernese Mountain Dog, click here for more information.
For bernese Mountain Dog we have a special offer for both Exon 1 and Exon 2 at reduced price, click here for more details.
2 ) Episodic Falling in Cavalier King Charles Spaniel (EF)
Breeds
Cavalier King Charles Spaniel
,
Cavapoo
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Episodic Falling is a genetic neurological disorder found in Cavalier King Charles Spaniels. Episodes are usually triggered by exercise, stress or excitement and are characterised by increased muscle tone and stiffness throughout the thoracic and pelvic limbs resulting in a characteristic 'deer-stalking' position and or collapse. The onset of symptoms is usually between fourteen weeks and four years of age but may appear at any age. Clinical symptoms vary in severity ranging from mild, occasional falling to freezing or seizure-like episodes lasting hours. Severity of the episodes can increase or decrease as the dog gets older. There is no standard pattern to the attacks.
The disease is also known as Exercise-Induced Paroxysmal Hypertonicity, Falling Cavaliers and Collapsing Cavalier Syndrome.
Prof. Dr. Robert Harvey of the London School of Pharmacy has recently identified the underlying genetic defect causing Episodic Falling in Cavalier King Charles Spaniels. LABOKLIN have recently implemented the genetic test for this disease under licence from the London School of Pharmacy. This test is currently patented within Europe, with Laboklin as the testing laboratory.
Trait of Inheritance
Episodic Falling is inherited as a autosomal recessive trait
It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
We will run this test 2 independant times on your sample to ensure that the result is 100% accurate
3 ) Dry Eye and Curly Coat syndrome (CCS)
Breeds
Cavalier King Charles Spaniel
,
Cavapoo
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Affected dog puppies suffer from keratoconjunctivitis sicca from eyelid opening, abnormal (rough/curly) coat and are usually smaller than littermates. Footpads are hyper keratinised from young adulthood including nail growth abnormalities and intermittent sloughing, pain and lameness.
Description
We also have a special offer:
Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT)
FOR BOTH TESTS.
Macrothrombocytopenia ( MTC ) is inherited as an autosomal dominant trait characterized by low platelet count and the presence of some larger than normal platelets in circulation.
Unlike acquired macrothrombocytopenia (thrombocytopenias secondary to infectious agents, medications, immune-mediated causes), this form does not respond to treatment.
It is important to note that these dogs may mistakenly be considered to have an underlying disease that results in thrombocytopenia, such as immune-mediated thrombocytopenia, tick-borne infection, or a bone marrow disorder.
TC ) is inherited as an autosomal dominant trait and results can be Clear (N/N), Affected heterozygous (N / MTC), Affected homozygous (MTC / MTC)
Muscular dystrophy (MD) in Cavalier King Charles Spaniel, Golden Retriever and Norfolk Terrier is a spontaneous, X-linked, progressively fatal disease of dogs and is also a homologue of Duchenne muscular dystrophy (DMD). Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. In American Staffordshire Terrier and Landseer, Muscular Dystrophy is inherited as an autosomal recessive trait. Affected dogs exhibit a general, whole body muscular weakness, they move slowly and clumsy and some cannot walk at all. First symptoms in the course of movement appear at the age of three to six month. Affected dogs usualy die between the ages of 4 and 24 months.
Australian Cattle Dog
,
Cavapoo
,
Cockapoo (English)
,
Cockapoo (American)
,
Dwarf poodle
,
English Setter
,
Gordon Setter
,
Irish Red and White Setter
,
Irish Setter (Red Setter)
,
Labradoodle
,
Miniature Poodle
,
Old Danish Pointing Dog
,
Polish Lowland sheepdog
,
Poodle
,
Small Munsterlander
,
Standard Poodle
,
Tatra Shepherd Dog (POP)
,
Tibetan Terrier
,
Toy Poodle
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in English Setter, Gordon Setter, Irish Setter (Red Setter), Standard Poodle, and Tibetan Terrier.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Progressive retinal atrophy (PRA) is a major hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated.
One can distinguish between late onset forms of PRA and early onset (whelp-age) dysplastic changes. The clinical and ophthalmologic signs of both forms are similar. Affected dogs suffer from bilateral Mydriasis, the reflection of the Tapetum lucidum is increased and the retinal vascular network appears atrophic.
The rcd4 PRA is another form of PRA, it is also known as LOPRA (Late Onset PRA) the age of onset of dogs with LOPRA varies from few years of age (2-3 years) up to old age (10-11 years)
It is very unlikely that the dog will develop Progressive retinal atrophy ( rcd4-PRA) / LOPRA. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Progressive retinal atrophy ( rcd4-PRA) / LOPRA but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Neonatal encephalopathy with seizures is an autosomal recessive developmental brain disease. Affected puppies exhibit extreme weakness, those that survive the first week of life generally develop progressively worse ataxia and a whole-body tremor. This is often accompanied by severe generalized clonic-tonic seizures. None have survived to 7 weeks of age. ´The mutation that is suggested to be responsible for NEWS in standard poodles can be detected via DNA-testing.
It is very unlikely that the dog will develop Neonatal encephalopathy (NE / NEWS). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Neonatal encephalopathy (NE / NEWS) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Kennel Club: results of this test is accepted by the Kennel Club
Breeds
All Dog Breeds
,
American Cocker Spaniel
,
American Eskimo
,
Australian Cattle Dog
,
Australian Shepherd
,
Australian Stumpy Tail Cattle Dog
,
Australian Stumpy tail cattle Dog
,
Barbet (French Water Dog)
,
Bearded Collie
,
Bolognese
,
Bolonka Zwetna (Tsvetnaya Bolonki)
,
Cavapoo
,
Chesapeake Bay Retriever
,
Chihuahua
,
Chinese Crested
,
Cockapoo (English)
,
Cockapoo (American)
,
Cocker Spaniel
,
Dwarf poodle
,
English Cocker Spaniel
,
English shepherd
,
Entlebuch Mountain dog
,
Finnish Lapphund
,
German Spitz (Mittel)
,
Giant Schnauzer
,
Golden Retriever
,
Goldendoodle
,
Jack Russell Terrier
,
Japanese Chin
,
Karelian Bear Dog
,
Kuvasz
,
Labradoodle
,
Labrador Retriever
,
Lagotto Romagnolo
,
Lapponian Herder
,
Markiesje
,
Miniature Poodle
,
Miniature American Shepherd
,
Norwegian Elkhound
,
Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
,
Parson Russell Terrier (PRT)
,
Poodle
,
Portuguese Waterdog
,
Schipperke
,
Australian Silky Terrier
,
Spanish Water Dog
,
Standard Poodle
,
Swedish Lapp Hund
,
Toy Poodle
,
Waeller (Wäller)
,
Yorkshire Terrier
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in American Cocker Spaniel, Australian Cattle Dog, Australian Shepherd, Barbet (French Water Dog), Chesapeake Bay Retriever, Chinese Crested, Cocker Spaniel, English Cocker Spaniel, Entlebuch Mountain dog, Finnish Lapphund, Giant Schnauzer, Labrador Retriever, Miniature Poodle, Norwegian Elkhound, Nova Scotia Duck tolling Retriever ( NSDTR / Toller), Portuguese Waterdog, Spanish Water Dog, Standard Poodle, and Toy Poodle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
Progressive retinal atrophy (PRA) as an inherited disease occurs in many dog breeds and also in different forms. The form of progressive rod-cone degeneration (prcd-PRA) is a photoreceptor degeneration in dogs with varying ages of onset. This genetic disorder causes the degeneration of retinal cells in the eye: firstly, rod cells are affected, thus leading to progressive night blindness. Secondly, degeneration of the cone cells results in complete blindness of the dog, even in full light situations during the day.
Age of onset of clinical symptoms is typically in early adolescence or early adulthood. However, the onset of the disease may vary among different dog breeds.
Since diagnosis of retinal diseases in dogs may prove difficult, the genetic test on prcd-PRA helps to diagnose a specific disease and is also a useful tool for breeders to eliminate the mutated gene from the dog population.
The mutation in the PRCD gene which has been suggested to cause prcd-PRA has recently been published by the group of Gustavo D. Aguirre at the University of Pennsylvania, USA, and could be found in several dog breeds.
Prcd-PRA is inherited as an autosomal recessive trait. So there are three conditions a dog can be: it can be clear (genotype N/N or homozygous normal) meaning that it does not carry the mutation and will not develop the prcd-form of PRA. Since it also cannot pass the mutation onto its offspring, it can be mated to any other dog.
A dog which has one copy of the PRCD gene with the mutation and one copy without the mutation is called a carrier or heterozygous (genotype N/PRA); while it will not be affected by prcd-PRA, it can pass the mutation onto its offspring and should therefore only be mated to clear dogs.
Dogs that develop this form of PRA have two PRCD gene copies with the mutation (genotype PRA/PRA or homozygous affected); they will always pass the mutated gene onto their offspring and should also be mated only to clear dogs..
It is very unlikely that the dog will develop Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Barbet (French Water Dog)
,
Bernese Mountain Dog
,
Cavapoo
,
Cockapoo (English)
,
Cockapoo (American)
,
Coton de Tulear
,
Doberman Pinscher
,
Drentsche Patrijschond
,
English Toy Terrier
,
German Pinscher
,
Goldendoodle
,
Irish Red and White Setter
,
Irish Setter (Red Setter)
,
Kerry Blue Terrier
,
Kromfohrländer
,
Labradoodle
,
Manchester Terrier
,
Miniature Poodle
,
Papillon (Continental Toy Spaniel )
,
Pembroke Welsh Corgi
,
Poodle
,
Stabyhound ( Stabijhoun )
,
Standard Poodle
,
Toy Poodle
.
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Doberman Pinscher, Manchester Terrier, Papillon (Continental Toy Spaniel ), and Standard Poodle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
The Disease
We are pleased to announce that Laboklin obtained an exclusive European License to perform this important genetic tes from Vet Gen LCC the owner of the European patentt.
Von Willebrand disease (vWD) is probably the most common inherited bleeding disorder in dogs. It is caused by lack of von Willebrand factor which is a protein that plays a key role in the blood clotting process resulting in prolonged bleeding. The disorder occurs in varying degrees of severity ranging from trivial bleeding to excessive life threatening haemorrhages.
Clinical Signs
Symptoms include spontaneous bleeding from the nose, gum and other mucous membranes. Excessive bleeding occurs after an injury, trauma or a surgery. Often dogs don’t show clinical signs until something starts the bleeding, such as nail trimming, teething, spaying, sterilizing, tail docking, cropping or other causes. Bleeding also occurs internally in the stomach, intestines, urinary tracts, the genitals and / or into the joints.
Type I von Willebrand's disease is considered relatively mild when compared to Type II in Scotch Terriers and Shetland Sheep Dogs and Type III in the German Wirehaired pointer, Type II and Type III are much more severe than type I.
Trait of Inheritance
vWD Type I is transmitted as autosomal incomplete dominant trait . This means that a dog that is genetically clear (also called homozygous normal) will not develop the vWD disorder and will not pass it to its offspring. Carrier dogs which carries one copy of the abnormal gene and another normal copy (also known as heterozygous) will have bleeding tendency. These carrier dogs will pass the abnormal gene to their offspring with a probability of 50%, the trait is called incomplete dominance because carrier dogs may not develop the disorder at all but they will still pass the abnormal gene to their offspring. Because it is very uncommon for carriers to show symptoms of vWD this condition is treated as Recessive. Affected dogs (carry two copies of the abnormal gene) will develop the vWD disorder and will pass the abnormal gene to each of their offspring
The Mutation-based Test and its Advantages
A new DNA test has now been developed for the type I vWD.
Genetic testing makes it possible to identify whether a dog is clear, carrier or affected. This is vital to eliminate this condition from the breed within 2-3 generations.
The new DNA test can identify the responsible mutation directly.
This DNA test can be done at any age and unambiguously classifies dogs into affected, carriers and clear. The test enables breeders to eliminate the vWD disease gene from the Poodles. Carriers can be clinically normal because of a low penetrance or expressivity of the disease. This information is essential for controlling this disorder in the breed.
Breeders and owners should view vWD as a significant health risk and strive to get rid of the mutated gene. The discovery of the mutation, and the recent development of a DNA test, now provides just that opportunity.
Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form
<Request sample collection
materials> or email: info@laboklin.co.uk.
