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Colour dilution (dilute ) and neurological defects ( CDN )
Test number: 8758
Gene Name: CDN
Short Name: CDN
Price: £ 48.00 (including VAT)
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Breeds
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Dachshund
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Miniature Long Haired Dachshund
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Miniature Smooth Haired Dachshund
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The Disease |
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In Miniature Dachshund, a variant in the gene MYO5A gene has been found to cause Coat Colour Dilution and Neurological Defects (CDN) resembling the human Griscelli Syndrome Type I.
An affected 4-weeks old puppy showed a diluted, light red coat colour. Despite normally developed external features, the puppy was unable to hold a normal prone position, fell on its side and rowed with the upper front legs. Furthermore, it was unable to maintain an upright head position or to coordinate head movements and hardly reacted to environmental stimuli. The histopathological findings were a multifocal accumulation of melanin and a deposition of clumped keratin in the follicular epithelium of haired skin. Due to the severity of symptoms, the puppy was euthanized. A frameshift mutation in the MYO5A gene has been identified, myosin VA- mediated transport plays a crucial role in neurons and the cerebellum and also in melanosome transport into growing hair shafts. |
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Colour dilution (dilute ) and neurological defects ( CDN ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CDN [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Colour dilution (dilute ) and neurological defects ( CDN ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CDN / CDN [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Colour dilution (dilute ) and neurological defects ( CDN ) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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