|
Kromfohrländer / Kromfohrlander DNA bundle (DM2+DH/HFH+Furnishing+HUU+MDR1+vWD1)
Test number: 8755
Price: £ 138.00 (including VAT) for all 6 tests
|
|
|
|
|
|
1 ) Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2) / SOD1
|
|
Breeds
|
|
Airedale Terrier
,
Alaskan Malamute
,
All Dog Breeds
,
American Eskimo
,
Bernese Mountain Dog
,
Bloodhound
,
Borzoi (Russian Wolfhound)
,
Boxer
,
Cavalier King Charles Spaniel
,
Canaan Dog
,
Welsh Corgi (Cardigan)
,
Chesapeake Bay Retriever
,
Cockapoo (English)
,
Cockapoo (American)
,
Fox Terrier
,
French Bull Dog
,
German Shepherd
,
Glen Of Imaal Terrier ( GIT )
,
Golden Retriever
,
Goldendoodle
,
Pyrenean Mountain Dog (Great Pyrenees)
,
Hovawart
,
Pumi ( Hungarian Pumi / Pumik )
,
Jack Russell Terrier
,
Kerry Blue Terrier
,
Labradoodle
,
Labrador Retriever
,
Lakeland Terrier
,
Northern Inuit (Tamaskan / British Timber Dog)
,
Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
,
Pembroke Welsh Corgi
,
Poodle
,
Pug
,
Rhodesian Ridgeback
,
Rough Collie
,
Soft Coated Wheaten Terrier
,
Shetland Sheepdog (Sheltie)
,
Smooth Collie
,
Utonagan
,
Wire Fox Terrier
.
|
|
|
|
Kennel Club
|
|
This test is part of the Official UK Kennel Club DNA Testing Scheme in Chesapeake Bay Retriever, French Bull Dog, German Shepherd, Nova Scotia Duck tolling Retriever ( NSDTR / Toller), Rough Collie, and Smooth Collie.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
|
|
|
|
The Disease |
|
Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including German Shepherds, Boxers, Chesapeake Bay Retrievers, Rhodesian Ridgebacks, and both breeds of Welsh Corgis. The disease is chronic and progressive, and resulting in paralysis.
|
|
|
|
|
Clinical Signs |
|
Degenerative myelopathy initially affects the back legs and causes muscle weakness and loss, and lack of coordination. These cause a staggering effect that may appear to be arthritis. The dog may drag one or both rear paws when it walks. This dragging can cause the nails of one foot to be worn down. The condition may lead to extensive paralysis of the back legs. As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking. If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy. Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia.
Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive up to three years
|
|
|
|
Trait of Inheritance |
|
Tow alleles are invloved in Degenerative Myelopathy, A and G, therefore a test result can be A/A, A/G, or G/G.
Mode of inheritance is autosomal recessive with variable penetrance;
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
| |
|
|
|
|
|
clear
|
 |
clear
|
 |
100% clear
|
| |
|
|
|
|
|
clear
|
|
carrier
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
clear
|
|
affected
|
|
100% carriers
|
| |
|
|
|
|
|
carrier
|
|
clear
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
carrier
|
|
carrier
|
|
25% clear + 25% affected
+ 50% carriers
|
| |
|
|
|
|
|
carrier
|
|
affected
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
clear
|
|
100% carriers
|
| |
|
|
|
|
|
affected
|
|
carrier
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
affected
|
|
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Carrier
Genotype: N / DM (Exon 2) [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Affected
Genotype: DM (Exon 2) / DM (Exon 2) [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog may or may not show signs of the disease
|
|
|
| |
| |
| |
|
2 ) Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet)
|
|
Breeds
|
|
Dogue de Bordeaux (French Mastiff)
,
Irish Terrier
,
Kromfohrländer
.
|
|
|
|
Kennel Club
|
|
This test is part of the Official UK Kennel Club DNA Testing Scheme in Irish Terrier.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
|
|
|
|
The Disease |
 |
 |
|
This disease is also called “Corny Feet” as the main symptom is thickening and hardening of the footpads. Affected dogs suffer from painful cracks and crevices sometimes leading to secondary infections. Additionally, nail growth is accelerated so that nails become deformed and crumbly. As footpads and nails are cared for, the dog's lifespan and quality of life are normal.
|
|
|
|
|
Trait of Inheritance |
|
Autosomal recessive mode of inheritance (see interpretation below)
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
| |
|
|
|
|
|
clear
|
|
clear
|
|
100% clear
|
| |
|
|
|
|
|
clear
|
|
carrier
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
clear
|
|
affected
|
|
100% carriers
|
| |
|
|
|
|
|
carrier
|
|
clear
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
carrier
|
|
carrier
|
|
25% clear + 25% affected
+ 50% carriers
|
| |
|
|
|
|
|
carrier
|
|
affected
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
clear
|
|
100% carriers
|
| |
|
|
|
|
|
affected
|
|
carrier
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
affected
|
|
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / DH [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: DH / DH [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet) and will pass the mutant gene to its entire offspring
|
|
|
| |
| |
|
3 ) Furnishings
|
|
Breeds
|
|
All Dog Breeds
,
Barbet (French Water Dog)
,
Griffon Bruxellois (Brussels Griffon)
,
Chinese Crested
,
Dachshund
,
German Wirehaired Pointer
,
Havana Silk Dog
,
Havanese - Bichon Havanese
,
Hungarian Vizsla (Magyar Vizsla / Smooth haired)
,
Lagotto Romagnolo
,
Soft Coated Wheaten Terrier
,
Various dog breeds
,
Hungarian Wirehaired Vizsla (Vizslak)
.
|
|
|
|
Description |
|
Furnishings refer to the longer facial hair around the eyebrows, moustache, and beard commonly seen in many breeds, including the wirehaired breeds. Presence of furnishings is dominant to the unfurnished version of the gene, which depending on breed may also be referred to as satin, or sleek. LABOKLIN offers a test to see if a furnished dog carries the recessive unfurnished trait. This coat variant is called 'improper coat' in portuguese waterdogs. In Hungarian Wirehaired Vizsla (Vizslak) this it is called Wirehair.
|
|
|
|
| |
|
| |
| |
|
4 ) Hyperuricosuria / Urate Stones (HUU, SLC)
|
|
New Kennel Club DNA testing scheme for HUU in Dalmatian |
The Kennel Club has agreed a new DNA testing scheme for Hyperuricosuria (HUU) / Urate Stone Disorder (USD) in Dalmatian. Under this scheme, HUU test results can be sent by Laboklin to the Kennel Club to be recorded and published only if the submission and testing procedure complies with the following protocol:
- that dogs to be tested are microchipped and registered before the test sample is taken;
- that the test sample (whether buccal swab or EDTA blood sample or other) is taken by a veterinary surgeon or veterinary nurse who first confirms the microchip identity of the test subject and records both the microchip number and registration name on the sample container/package;
- that the sample is sent directly by the veterinary surgery to LABOKLIN.
Copies of all future test certificate results issued by LABOKLIN will only be recorded by the Kennel Club at this time provided they comply with the above protocols.
Please ensure that the veterinary surgeon or veterinary nurse taking the sample complete the vet section on the order form, sign it and stamp it, send it directly to Laboklin and ensure that there stamp is on the package / envelope containing the samples submitted. |
|
|
|
|
Breeds
|
|
All Dog Breeds
,
Russian Black Terrier ( RBT )
,
Bulldog (English)
,
Dalmatian
,
Hungarian Vizsla (Magyar Vizsla / Smooth haired)
,
Large Munsterlander
,
Spanish Water Dog
,
Weimaraner
,
Hungarian Wirehaired Vizsla (Vizslak)
.
|
|
|
|
Kennel Club
|
|
This test is part of the Official UK Kennel Club DNA Testing Scheme in Russian Black Terrier ( RBT ), Bulldog (English), Dalmatian, Large Munsterlander, and Hungarian Wirehaired Vizsla (Vizslak).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
|
|
|
|
The Disease |
Hyperuricosuria is characterized by elevated levels of uric acid in the urine. This disease predisposes dogs to form stones in their bladders or sometimes kidneys. The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier. The mutation was recently described in Spanish Waterdog (https://www.ncbi.nlm.nih.gov/pubmed/26538670). Here at Laboklin we recently tested an Australian Shepherd as carrier of HUU but we have no information about its prevalence in this breed, and therefore testing recomended if your aussie is showing symptoms of the disease. |
|
|
|
|
Trait of Inheritance |
|
Hyperuricosuria is inherited as a simple autosomal recessive trait.
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
| |
|
|
|
|
|
clear
|
|
clear
|
|
100% clear
|
| |
|
|
|
|
|
clear
|
|
carrier
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
clear
|
|
affected
|
|
100% carriers
|
| |
|
|
|
|
|
carrier
|
|
clear
|
|
50% clear + 50%
carriers
|
| |
|
|
|
|
|
carrier
|
|
carrier
|
|
25% clear + 25% affected
+ 50% carriers
|
| |
|
|
|
|
|
carrier
|
|
affected
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
clear
|
|
100% carriers
|
| |
|
|
|
|
|
affected
|
|
carrier
|
|
50% carriers + 50%
affected
|
| |
|
|
|
|
|
affected
|
|
affected
|
|
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Hyperuricosuria / Urate Stones (HUU, SLC). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / SLC2 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Hyperuricosuria / Urate Stones (HUU, SLC) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SLC2 / SLC2 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Hyperuricosuria / Urate Stones (HUU, SLC) and will pass the mutant gene to its entire offspring
|
|
|
| |
| |
|
5 ) MDR1 Gene Varian / Ivermectin Sensitivity * (ABCB1)
|
|
Breeds
|
|
American White Shepherd
,
Australian Shepherd
,
Bobtail
,
Border Collie
,
Collie
,
Elo
,
English shepherd
,
German Shepherd
,
Kromfohrländer
,
Longhaired Whippet
,
McNab Shepherd (McNab Border Collie)
,
Miniature American Shepherd
,
Old English Sheepdog (Bobtail)
,
Rough Collie
,
Shetland Sheepdog (Sheltie)
,
Silken Windhound
,
Smooth Collie
,
Waeller (Wäller)
,
White Swiss Shepherd ( Berger Blanc Suisse )
.
|
|
|
|
Kennel Club
|
|
This test is part of the Official UK Kennel Club DNA Testing Scheme in Australian Shepherd, Border Collie, Rough Collie, Shetland Sheepdog (Sheltie), and Smooth Collie.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
|
|
|
|
The Disease |
MDR1 is a genetic disorder found in many dog breeds. Affected dogs, when treated with certain common drugs such as Ivermectin and loperamide (Imodium), are unable to pump out these drugs from the brain resulting in poisoning and neurologic symptoms ranging from tremors, anorexia and excess salivation to blindness, coma and even death. Some of these drugs such as Ivermectins, which vets prescribe extensively for the treatment of parasite infections, are able to cause toxicity at 1/200th of the dose required to cause toxicity in healthy dogs.
Scientists discovered that these dogs lack a protein (P-Glycoprotein), which is responsible for pumping out many drugs and toxins from the brain, and that affected dogs show signs of toxicity because they are unable to stop drugs from permeating their brains. Researchers have identified that this condition is due to a mutation in the multi-drug resistance gene [MDR1].
LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION
| Class A |
Do not use these drugs in dogs with MDR1 Gene Defect |
Ivermectine substances "Anti parasites": (Diapec®, Ecomectin®, Equimax®, Eqvalan®, Ivomec®, Noromectin®, Paramectin®, Qualimec®, Sumex®, Virbamec®)
Doramectine substances "Anti parasites": (Dectomax® )
Loperamide substances "ant diarrheal ":
(Imodium®)
Moxidectine substances "Anti Parasites" (Cydectin®, Equest®) |
Class B |
Use only under close control of veterinarian |
Cytostatics "Chemotherapy": (Vinblastine, Vincristine, Doxorubicine, Paclitaxel, Docetaxel, Methotrexat, Vincristine)
Immunosuppressive: (Cyclosporine A)
Heart glycosides: (Digoxine, Methyldigoxine)
Opioids: (Morphium)
Antiarrhythmics: (Verapamil, Diltiazem, Chinidine)
Antiemetics (Ondansetron, Domperidon, Metoclopramide )
Antibiotics (Sparfloxacin, Grepafloxacin, Erythromycin)
Antihistamin (Ebastin)
Glucocorticoid (Dexamethason)
Acepromazine (tranquilizer and pre-anesthetic agent) *
Butorphanol "analgesic and pre-anesthetic agent" *
Other drugs:
Etoposide, Mitoxantrone, Ondansetron, Paclitaxel, Rifampicin |
| Class C |
Can be used only in the permitted application form and dose! |
Selamectin (Stronghold®), Milbemax® and Advocate® . |
* In dogs with the MDR1 mutation, acepromazine and butorphanol tend to cause more profound and prolonged sedation in dogs . It is recommended to reduce the dose by 25% in dogs heterozygous for the MDR1 mutation (MDR1 / N) and by 30-50% in dogs homozygous for the MDR1 mutation (MDR1 / MDR1).
|
|
|
|
|
|
Trait of Inheritance |
|
Dogs that are homozygous for the mutation display, due to a non-functional transporter the ivermectin sensitive phenotype. They can show increased absorption of ivermectin and other substrates e.g. Digoxin, Vincristine, Doxorubicin, Cyclosporin A, Grepafloxacin, Dexamethasone and Loperamide (See list of drugs). Heterozygous animals (carriers) may show sensitivity to avermectins and other drugs. They are able to propagate the responsible mutation throughout the population and it is therefore important that carrier animals are detected prior to breeding.
Carriers mayhave sensitivity and should be treated with care
|
Inheritance : AUTOSOMAL
trait
|
|
|
|
Description |
|
This is a mutation-based gene test, which offers many advantages over other methods
The MDR1 gene variant can be detected, using molecular genetic testing techniques. By DNA testing the mutation can be shown directly. The testing is carried out by state of the art laboratory methods and therefore provides a very high accuracy. In general DNA tests can be done at any age. These tests identify both affected and carrier animals. The mutation can be shown directly, what clearly identifies homozygous affected animals. The genetic test offers the unique possibility to identify Ivermectin sensitive animals prior to treatment with Ivermectin and other drugs (see list). * partner lab
Please note drug list may not be up to date. The WSU Veterinary CLinical Pharmacology Lab may have a more updated list https://vcpl.vetmed.wsu.edu/problem-drugs. Please note that there maybe other problem drugs which may have not been yet identified.
|
|
|
|
| |
|
| |
| |
|
6 ) von Willebrand disease Type I (vWD I)
|
|
Breeds
|
|
Barbet (French Water Dog)
,
Bernese Mountain Dog
,
Cavapoo
,
Cockapoo (English)
,
Cockapoo (American)
,
Coton de Tulear
,
Doberman Pinscher
,
Drentsche Patrijschond
,
English Toy Terrier
,
German Pinscher
,
Goldendoodle
,
Irish Red and White Setter
,
Irish Setter (Red Setter)
,
Kerry Blue Terrier
,
Kromfohrländer
,
Labradoodle
,
Manchester Terrier
,
Miniature Poodle
,
Papillon (Continental Toy Spaniel )
,
Pembroke Welsh Corgi
,
Poodle
,
Stabyhound ( Stabijhoun )
,
Standard Poodle
,
Toy Poodle
.
|
|
|
|
Kennel Club
|
|
This test is part of the Official UK Kennel Club DNA Testing Scheme in Doberman Pinscher, Manchester Terrier, Papillon (Continental Toy Spaniel ), and Standard Poodle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
|
|
|
|
The Disease |
We are pleased to announce that Laboklin obtained an exclusive European License to perform this important genetic tes from Vet Gen LCC the owner of the European patentt.
Von Willebrand disease (vWD) is probably the most common inherited bleeding disorder in dogs. It is caused by lack of von Willebrand factor which is a protein that plays a key role in the blood clotting process resulting in prolonged bleeding. The disorder occurs in varying degrees of severity ranging from trivial bleeding to excessive life threatening haemorrhages. |
|
|
|
|
Clinical Signs |
Symptoms include spontaneous bleeding from the nose, gum and other mucous membranes. Excessive bleeding occurs after an injury, trauma or a surgery. Often dogs don’t show clinical signs until something starts the bleeding, such as nail trimming, teething, spaying, sterilizing, tail docking, cropping or other causes. Bleeding also occurs internally in the stomach, intestines, urinary tracts, the genitals and / or into the joints.
Type I von Willebrand's disease is considered relatively mild when compared to Type II in Scotch Terriers and Shetland Sheep Dogs and Type III in the German Wirehaired pointer, Type II and Type III are much more severe than type I. |
|
|
|
Trait of Inheritance |
|
vWD Type I is transmitted as autosomal incomplete dominant trait . This means that a dog that is genetically clear (also called homozygous normal) will not develop the vWD disorder and will not pass it to its offspring. Carrier dogs which carries one copy of the abnormal gene and another normal copy (also known as heterozygous) will have bleeding tendency. These carrier dogs will pass the abnormal gene to their offspring with a probability of 50%, the trait is called incomplete dominance because carrier dogs may not develop the disorder at all but they will still pass the abnormal gene to their offspring. Because it is very uncommon for carriers to show symptoms of vWD this condition is treated as Recessive. Affected dogs (carry two copies of the abnormal gene) will develop the vWD disorder and will pass the abnormal gene to each of their offspring
|
Inheritance :
trait
|
|
|
|
Description |
|
The Mutation-based Test and its Advantages
A new DNA test has now been developed for the type I vWD.
Genetic testing makes it possible to identify whether a dog is clear, carrier or affected. This is vital to eliminate this condition from the breed within 2-3 generations.
The new DNA test can identify the responsible mutation directly.
This DNA test can be done at any age and unambiguously classifies dogs into affected, carriers and clear. The test enables breeders to eliminate the vWD disease gene from the Poodles. Carriers can be clinically normal because of a low penetrance or expressivity of the disease. This information is essential for controlling this disorder in the breed.
Breeders and owners should view vWD as a significant health risk and strive to get rid of the mutated gene. The discovery of the mutation, and the recent development of a DNA test, now provides just that opportunity.
|
|
|
|
| |
| |
|
Price
for the above 6 tests
|
|
£ 138.00 (including VAT)
|
|
|
 |
|
|
|
|
