Subacute Necrotizing Encephalopathy (SNE) is a fatal hereditary neurodegenerative disorder affecting Yorkshire Terriers. The condition is caused by an autosomal recessive mutation in the SLC19A3 gene, which disrupts thiamine (vitamin B1) transport into nerve cells and leads to progressive loss of normal brain energy metabolism.
Clinical signs usually appear within the first year of life and include abnormal gait, ataxia, spasticity, central visual deficits, behavioural changes and reduced mental state. As the disease advances, affected dogs may develop worsening motor dysfunction, difficulty walking and episodes of collapse.
SNE is progressive and severely impacts quality of life, ultimately resulting in significant neurological impairment.
