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Welsh Corgi DNA bundle (Brachyuria + DM exon2 + rcd3-PRA + vWD1)
Test number: 8661
Price: £ 132.00 (including VAT) for all 4 tests
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1 ) Brachyury (Bobtail Gene / Short Tail / T-Box)
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Breeds
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Australian Shepherd
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Australian Stumpy tail cattle Dog
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Austrian Pinscher
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Bourbonnais Pointer (Bourbonnais Pointing Dog)
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Bouvier des Ardennes
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Brazilian Terrier
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Brittany ( Brittany Spaniel )
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Croatian Sheepdog
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Danish Farm Dog
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Jack Russell Terrier
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Karelian Bear Dog
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Miniature American Shepherd
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Mudi
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Polish Lowland sheepdog
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Pyrenean Shepherd
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Savoy Sheepdog
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Schipperke
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Spanish Water Dog
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Spanish Waterdog
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Swedish Farm Dog
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Swedish Vallhund
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Welsh Corgi
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Schipperke.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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Description |
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Bobtail gene: Brachyury / Anury (Bobtail Gene / Short Tail / T-Box)
The spine (or backbone) is made up of a series of small bones called vertebrae. The dog's tail is the last segment of the spine and it is made up of as many as 23 small vertebrae. Normal tail length and number of vertebrae varies considerably in dogs, however, the number within a breed will be the same or may vary by one or two.
Tail length depends on the number of the caudal vertebrae, which can vary significantly between individuals. The bones of the normal tail are bigger at the base and and gradually taper toward the tip, giving the impression of a point.
A natural bobtail is a dog's tail which grows unusually short or is missing completely due to a genetic mutation. A short tail with variable lengths is also referred to as Brachyury , and a complete lack of vertebrae is referred to as Anury In a bobtail, some of the vertebrae are missing; the end of the tail looks somewhat blunt.
The mutation that is responsible for the bobtail phenotype has been identified in many breeds (but not all bobtail breeds), the mutation is in the t-box gene, and a DNA test is available at Laboklin.
The trait of inheritance is autosomal dominant which means that when a dog inherits one copy of the mutation (heterozygous N/T) it will have a natural short tail.
Dogs with two copies (homozygous T/T) of the T-Box gene die in womb and reabsorbed resulting in smaller litter size. If puppies are born with two copies of the T-Box, they will have severe anatomical defects including Spina Bifida, which are severe enough to require euthanasia.
The test also helps in identifying if a dog is docked or if it has a natural short tail.
Possible results:
- N/N (Normal Homozygous for the normal allele): The dog has two copies of the normal gene and will have a normal tail.
- N/T:(Heterozygous) The dog carries one copy of the normal gene and one copy of the mutant gene; the dog has a natural short tail. Heterozygous dogs can pass the mutation to their offspring with a probability of 50%.
- T/T (Homozygous for the mutation) (T/T): does not exist and thought to be lethal.
Research found that there is no association between the bobtail mutation and the short tail phenotype in the following breeds:
- Boston Terrier
- English Bulldog
- King Charles Spaniel
- Miniature Schnauzer
- Parson Russell Terrier
- Rottweiler
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2 ) Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2) / SOD1
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Breeds
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Airedale Terrier
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Alaskan Malamute
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All Dog Breeds
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American Eskimo
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Bernese Mountain Dog
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Bloodhound
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Borzoi (Russian Wolfhound)
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Boxer
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Cavalier King Charles Spaniel
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Canaan Dog
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Welsh Corgi (Cardigan)
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Chesapeake Bay Retriever
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Cockapoo (English)
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Cockapoo (American)
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Fox Terrier
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French Bull Dog
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German Shepherd
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Glen Of Imaal Terrier ( GIT )
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Golden Retriever
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Goldendoodle
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Pyrenean Mountain Dog (Great Pyrenees)
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Hovawart
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Pumi ( Hungarian Pumi / Pumik )
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Jack Russell Terrier
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Kerry Blue Terrier
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Labradoodle
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Labrador Retriever
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Lakeland Terrier
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Northern Inuit (Tamaskan / British Timber Dog)
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Nova Scotia Duck tolling Retriever ( NSDTR / Toller)
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Pembroke Welsh Corgi
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Poodle
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Pug
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Rhodesian Ridgeback
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Rough Collie
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Soft Coated Wheaten Terrier
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Shetland Sheepdog (Sheltie)
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Smooth Collie
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Utonagan
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Wire Fox Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Chesapeake Bay Retriever, French Bull Dog, German Shepherd, Nova Scotia Duck tolling Retriever ( NSDTR / Toller), Rough Collie, and Smooth Collie.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including German Shepherds, Boxers, Chesapeake Bay Retrievers, Rhodesian Ridgebacks, and both breeds of Welsh Corgis. The disease is chronic and progressive, and resulting in paralysis.
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Clinical Signs |
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Degenerative myelopathy initially affects the back legs and causes muscle weakness and loss, and lack of coordination. These cause a staggering effect that may appear to be arthritis. The dog may drag one or both rear paws when it walks. This dragging can cause the nails of one foot to be worn down. The condition may lead to extensive paralysis of the back legs. As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking. If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy. Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia.
Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive up to three years
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Trait of Inheritance |
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Tow alleles are invloved in Degenerative Myelopathy, A and G, therefore a test result can be A/A, A/G, or G/G.
Mode of inheritance is autosomal recessive with variable penetrance;
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Carrier
Genotype: N / DM (Exon 2) [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy
Affected
Genotype: DM (Exon 2) / DM (Exon 2) [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog may or may not show signs of the disease
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3 ) Progressive Retinal Atrophy (rcd3 PRA)
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Breeds
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Welsh Corgi (Cardigan)
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Chinese Crested
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Pomeranian
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Welsh Corgi (Cardigan).
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated.
Pups show signs of night-blindness by 6 weeks of age. By the age of 1-2 years most affected dogs are completely blind.
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Trait of Inheritance |
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rcd3 PRA follows an autosomal recessive trait of inheritance.
Since vision loss might be recognised first when the dog is several years old, it is important to determine the actual status of the dog before breeding it.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy (rcd3 PRA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / PRA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy (rcd3 PRA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: PRA / PRA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Progressive Retinal Atrophy (rcd3 PRA) and will pass the mutant gene to its entire offspring
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Description |
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Progress in molecular genetics has allowed the identification of the gene mutation responsible for PRA.
By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed.
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4 ) von Willebrand disease Type I (vWD I)
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Breeds
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Barbet (French Water Dog)
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Bernese Mountain Dog
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Cavapoo
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Cockapoo (English)
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Cockapoo (American)
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Coton de Tulear
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Doberman Pinscher
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Drentsche Patrijschond
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English Toy Terrier
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German Pinscher
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Goldendoodle
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Irish Red and White Setter
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Irish Setter (Red Setter)
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Kerry Blue Terrier
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Kromfohrländer
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Labradoodle
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Manchester Terrier
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Miniature Poodle
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Papillon (Continental Toy Spaniel )
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Pembroke Welsh Corgi
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Poodle
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Stabyhound ( Stabijhoun )
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Standard Poodle
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Toy Poodle
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Doberman Pinscher, Manchester Terrier, Papillon (Continental Toy Spaniel ), and Standard Poodle.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
We are pleased to announce that Laboklin obtained an exclusive European License to perform this important genetic tes from Vet Gen LCC the owner of the European patentt.
Von Willebrand disease (vWD) is probably the most common inherited bleeding disorder in dogs. It is caused by lack of von Willebrand factor which is a protein that plays a key role in the blood clotting process resulting in prolonged bleeding. The disorder occurs in varying degrees of severity ranging from trivial bleeding to excessive life threatening haemorrhages. |
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Clinical Signs |
Symptoms include spontaneous bleeding from the nose, gum and other mucous membranes. Excessive bleeding occurs after an injury, trauma or a surgery. Often dogs don’t show clinical signs until something starts the bleeding, such as nail trimming, teething, spaying, sterilizing, tail docking, cropping or other causes. Bleeding also occurs internally in the stomach, intestines, urinary tracts, the genitals and / or into the joints.
Type I von Willebrand's disease is considered relatively mild when compared to Type II in Scotch Terriers and Shetland Sheep Dogs and Type III in the German Wirehaired pointer, Type II and Type III are much more severe than type I. |
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Trait of Inheritance |
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vWD Type I is transmitted as autosomal incomplete dominant trait . This means that a dog that is genetically clear (also called homozygous normal) will not develop the vWD disorder and will not pass it to its offspring. Carrier dogs which carries one copy of the abnormal gene and another normal copy (also known as heterozygous) will have bleeding tendency. These carrier dogs will pass the abnormal gene to their offspring with a probability of 50%, the trait is called incomplete dominance because carrier dogs may not develop the disorder at all but they will still pass the abnormal gene to their offspring. Because it is very uncommon for carriers to show symptoms of vWD this condition is treated as Recessive. Affected dogs (carry two copies of the abnormal gene) will develop the vWD disorder and will pass the abnormal gene to each of their offspring
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Inheritance :
trait
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Description |
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The Mutation-based Test and its Advantages
A new DNA test has now been developed for the type I vWD.
Genetic testing makes it possible to identify whether a dog is clear, carrier or affected. This is vital to eliminate this condition from the breed within 2-3 generations.
The new DNA test can identify the responsible mutation directly.
This DNA test can be done at any age and unambiguously classifies dogs into affected, carriers and clear. The test enables breeders to eliminate the vWD disease gene from the Poodles. Carriers can be clinically normal because of a low penetrance or expressivity of the disease. This information is essential for controlling this disorder in the breed.
Breeders and owners should view vWD as a significant health risk and strive to get rid of the mutated gene. The discovery of the mutation, and the recent development of a DNA test, now provides just that opportunity.
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Price
for the above 4 tests
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£ 132.00 (including VAT)
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