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1 ) Spongy Degeneration with Cerebellar Ataxia ( SDCA1 )
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Breeds
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Belgian Shepherd Dog (Malinois)
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Belgian Shepherd Dog
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Dutch Shepherd
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The Disease |
Spongy Degeneration with Cerebellar Ataxia, (SDCA2) is an inherited disease affecting the Belgian Shepherd breed. It is a severe neurodegenerative disease with monogenic autosomal recessive inheritance. The disease is characterised by rapidly progressing ataxia starting around the age of 5-8 weeks. Puppies are usually euthanised by the age of 8-12 weeks. The disease can also be caused by another mutation SDCA2 . We also offer a combined SDCA1 + SDCA2 test in this breed. |
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / SDCA1 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SDCA1 / SDCA1 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ) and will pass the mutant gene to its entire offspring
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2 ) Spongy Degeneration with Cerebellar Ataxia ( SDCA2 )
|
|
Breeds
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|
Belgian Shepherd Dog (Malinois)
,
Belgian Shepherd Dog
,
Dutch Shepherd
.
|
|
|
|
The Disease |
Spongy Degeneration with Cerebellar Ataxia, (SDCA2) is an inherited disease affecting the Belgian Shepherd breed. It is a severe neurodegenerative disease with monogenic autosomal recessive inheritance. The disease is characterised by rapidly progressing ataxia starting around the age of 5-8 weeks. Puppies are usually euthanised by the age of 8-12 weeks. The disease can also be caused by another mutation SDCA1 . We also offer a combined SDCA1 + SDCA2 test in this breed. |
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / SDCA2 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SDCA2 / SDCA2 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ) and will pass the mutant gene to its entire offspring
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3 ) Cardiomyopathy with Juvenile Mortality (CJM)
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Breeds
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Belgian Shepherd Dog (Malinois)
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Belgian Shepherd Dog
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The Disease |
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Cardiomyopathy and juvenile mortality (CJM) is an inherited disease affecting the Belgian Shepherd breed. The genetic variant that is associated with this disease has been identified and the test is now available at Laboklin. Affected puppies die at birth or at a maximum age of 6-8 weeks. In the latter case, puppies initially develop normally but then show unspecific symptoms like vomiting, uncoordinated movements, trembling or respiratory symptoms and die a few days after the first clinical signs, usually due to heart failure. The genetic analysis of CJM enables the selective mating of breeding dogs. Due to the autosomal recessive trait of inheritance, two copies of the mutation are required to cause the disease, and therefore dogs tested as carriers should not be removed from breeding but should only be bred with clear dogs to avoid having affected puppies.
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Trait of Inheritance |
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autosomal recessive trait
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Cardiomyopathy with Juvenile Mortality (CJM). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / CJM [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Cardiomyopathy with Juvenile Mortality (CJM) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CJM / CJM [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Cardiomyopathy with Juvenile Mortality (CJM) and will pass the mutant gene to its entire offspring
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4 ) CNS Atrophy with Cerebellar Ataxia (CACA)
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Breeds
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Belgian Shepherd Dog (Malinois)
,
Belgian Shepherd Dog
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The Disease |
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Our cooperation partner Prof. Tosso Leeb and his team from the University of Bern have identified a new genetic variant causing a neurological disease called CNS atrophy and cerebellar ataxia (CACA) in the breed Belgian Shepherd.
Affected puppies show uncoordinated movements, intention tremor, short episodes of spastic fits, general elevated muscle tone and a reduced swallowing reflex. Moreover, affected puppies show less body weight increase as their unaffected littermates. First signs could be observed at the age of about 2 weeks. However, the severity of the signs are highly variable.
Many affected puppies have to be euthanized a few weeks after the first signs whereas an affected dog with less intense symptoms has been reported to become up to 10 years old.
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Trait of Inheritance |
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trait of inheritance is autosomal recessive
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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| |
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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|
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop CNS Atrophy with Cerebellar Ataxia (CACA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop CNS Atrophy with Cerebellar Ataxia (CACA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: / [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop CNS Atrophy with Cerebellar Ataxia (CACA) and will pass the mutant gene to its entire offspring
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Price
for the above 4 tests
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£ 126.00 (including VAT)
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