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Protein Losing Nephropathy (PLN)
Test number: 8492 (this test number replaces the old 8307D)
Gene Name: PLN
Short Name: PLN
Price: £ 48.00 (including VAT)
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Complex polygenic trait of inheritance.
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Breeds
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Airedale Terrier
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Soft Coated Wheaten Terrier
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The Disease |
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Protein Losing Nephropathy (PLN) is an inherited disease that affect Soft-Coated Wheaten Terriers and results in essential proteins being lost through the kidney. The disease can be mild and stable for years, however, it may lead to severe complications including kidney failure. Progression of the symptoms is variable and often influenced by environmental factors.
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Clinical Signs |
Symptoms include but not limited to depression, decreased appetite, vomiting, weight loss, Ascites, oedema, pleural effusion and Increased water consumption.
Lab tests shows decreased blood albumin levels and elevated urine proteine / creatinine ratio, and sometimes Elevated serum creatinine, BUN (later), Hypercholesterolemia, Elevated MA (Microalbuminuria). Laboratory abnormalities are not seen in every case. |
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Description |
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Diagnosis of PLN has always been difficult, especially in the early stages of the disease, it can be misdiagnosed as liver, gland or other kidney diseases. Thanks to advances in molecular biology, teh mutation associated with PLN has been identified and Laboklin can now offer a DNA testfor PLN in Soft-Coated Wheaten Terriers.
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Trait of Inheritance |
Clear (N/N) Description: Dogs with this genotype have the lowest risk of developing PLN. They do not inherit any copies of the PLN-associated genetic mutations, making them the least susceptible to the disease. Transmission: These dogs will not pass the PLN-associated mutation to their offspring. All their puppies will receive a normal (N) allele from them. Heterozygous (N/PLN) Description: Dogs with this genotype have a low to intermediate risk of developing PLN. They inherit one copy of the PLN-associated genetic mutation, which increases their risk compared to dogs with no copies but not as much as those with two copies. Transmission: These dogs have a 50% chance of passing the PLN-associated mutation (PLN) to their offspring. Each puppy has an equal chance of inheriting either the normal (N) allele or the PLN-associated mutation. Homozygous Positive (PLN/PLN) Description: Dogs with this genotype have the highest risk of developing PLN. They inherit two copies of the PLN-associated genetic mutations, significantly increasing their susceptibility to the disease. Transmission: These dogs will pass the PLN-associated mutation to all their offspring. Every puppy will inherit one PLN allele from the homozygous positive parent. Summary Table
| Genotype | Risk Level | Transmission to Offspring |
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N/N (Clear) | Lowest | Will pass only normal (N) alleles | | N/PLN | Low to Intermediate | 50% chance of passing PLN mutation | | PLN/PLN | Highest | Will pass PLN mutation to all offspring |
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Inheritance : AUTOSOMAL
COMPLEX POLYGENIC
trait
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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