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Mycobacterium Avium Complex ( MAC ) sensitivity
Test number: 8360
Gene: CARD9
Price: £ 48.00 (including VAT)
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Breed
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Miniature Schnauzer
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Miniature Schnauzer.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Immunodeficiencies represent a large heterogenous group of dysfunctions of the
host’s immune system which increase the risk for infections. While dogs are generally
resistant to Mycobacterium avium infections, a variant has been found to be
associated with a genetic predisposition to infection with systemic avian tuberculosis
in Miniature Schnauzers (referred to mycobacterium avium complex or MAC). The
described variant in the CARD9 gene most likely impairs a signaling pathway which
is important for the dog’s immunodeficiency. Common symptoms of affected dogs
are: lethargy, inappetence, weakness, nasal discharge, conjunctivitis, diarrhea,
lymphadenopathy, hepatomegaly and splenomegaly. The age of onset varies
between one and eight years. Because of the underlying immunodeficiency, the
infections are poorly responsive to treatment and often recur. Since MAC is a
zoonotic disease, humans with a suppressed immune system could be also at risk for
an infection.
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Price
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£ 48.00 (including VAT)
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