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Severe Combined Immunodeficiency (SCID)
Test number: 8328
Gene Name: RAG1
Short Name: SCID
Price: £ 48.00 (including VAT)
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Breeds
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Frisian Water Dog
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Description |
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Severe combined immunodeficiency (SCID) is an inherited disorder affecting the immune system resulting in immunodeficiency that predisposes the dog to recurrent infections. The mutation leads to dysfunction of the T and B Lymphocytes. Clinical symptoms typically begins at around 7-8 weeks if age and includes failure to thrive, lethargy, poor growth, weight loss, seizures, diarrhea, vomiting, ataxia, blindness and lack of palpable lymph nodes. Affected dogs die within 4 months of age.
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Trait of Inheritance |
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Severe Combined Immunodeficiency (SCID). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / SCID [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Severe Combined Immunodeficiency (SCID) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SCID / SCID [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Severe Combined Immunodeficiency (SCID) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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