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Canine Cyclic Neutropenia (Gray Collie Syndrome)
Test number: 8098
Gene Name: GCS
Short Name: GCS
Price: £ 48.00 (including VAT)
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Breeds
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Rough Collie
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Smooth Collie
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The Disease |
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Canine Cyclic Neutropenia is a genetic disorder that affects the stem cells, which are located in the bone marrow and are responsible for developing all blood cells in the body. This disorder leads to cyclic fluctuation in the number of blood cells, the number of the neutrophil blood cells falls down sharply every 10 to 12 days, and then it returns to normal.
Affected puppies look weaker and smaller than their litter siblings and have a noticeable pale gray, pinkish gray or beige coat colour. Due to the changing number of blood cells, the puppies become susceptible to all sorts of infections and by the age of 10 to 12 weeks they start exhibiting various clinical signs such as fever, diarrhoea, eye and/or respiratory infections. Puppies rarely live beyond the age of 3 years and usually die within few weeks after birth.
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Trait of Inheritance |
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The disease is inherited in an autosomal recessive trait. Both the parents must carry the abnormal gene for their puppies to be affected. Carrier dogs do not manifest the disease; however they can spread the abnormal gene to the next generations. Therefore reliable information of dogs that do not carry abnormal genes is the key to controlling this disease.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Canine Cyclic Neutropenia (Gray Collie Syndrome). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / GCS [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Canine Cyclic Neutropenia (Gray Collie Syndrome) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: GCS / GCS [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Canine Cyclic Neutropenia (Gray Collie Syndrome) and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
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Buccal swabs and EDTA tubes are available from
us free of charge, to order, please use the
online form:
- If
you are sending swab samples, please follow the
instructions on this link .
- Download your copy of the Genetics Tests Catalogue from this link
Our catalogue includes a complete list of all available DNA tests, along with their corresponding test numbers.
- If you have any queries, please contact us on
0161 282 3066
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| See also: |
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