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PKD (Feline Polycystic Kidney Disease)
Test number: 8046 (this test number replaces the old 8013CGD)
Gene: PKD
Price: £ 48.00 (including VAT)
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Breeds
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Turkish Angora
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British Shorthair (BSH)
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Birman (Sacred cat of Burma)
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British Longhair (BLH)
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Chartreux
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Colourpoint
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Exotic Shorthair
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Persian
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Persian Ragdoll
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Persian Related
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Ragdoll
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Ragdoll Related
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Russian Blue
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Scottish Fold Longhair
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Scottish Fold Shorthair
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Selkirk Rex Longhair
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Selkirk Rex Shorthair
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The Disease |
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Feline polycystic kidney disease is an inherited disease in Persian and Persian related cats. Approximately 38 % of Persian cats world-wide are positive for PKD, which is 6% of cats in total, making it the most prominent inherited feline disease. PKD causes the formation of hepatic and renal cysts as well as of fluid-filled renal cysts, often leading to renal failure.
Cystic kidneys can sporadically occur in any population of cats, but early onset and bilateral presentation is a hallmark to the hereditary form. The kidney cysts for PKD are present early, generally before 12 months, but renal failure generally occurs at a later time, thus it is considered a late onset renal disease. The presence of cystic kidneys can be determined by 6 to 8 months of age by ultrasonic techniques and affection diagnosis is generally certain by one to two years. Average age for renal dysfunction, not failure, is 7 years for cats with PKD. Thus, with out imaging techniques, cats would go undiagnosed for PKD for many years. Clinical signs are non specific but common to cats experiencing renal dysfunction, including depression, anorexia, reduced appetite, polyuria, polydypsia, and weight loss.
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Trait of Inheritance |
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PKD is inherited as a single autosomal dominant condition. Heterozygous animals show all clinical signs of disease and can not live normal lives. They are able to propagate mutations throughout the population. Generally, 50% of a PKD positive cats' offspring will inherit PKD.
Homozygous affected animals for PKD have not been found suggesting that the mutation in its homozygous form is embryonically lethal.
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Inheritance : AUTOSOMAL
DOMINANT
trait
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Description |
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PKD - the mutation
Recently, the mutation which is suggested to cause PKD in cats was found by Dr. Leslie Lyons (University of Davis, USA). This mutation was found in all PKD affected cats but not in cats which were tested free by means of ultrasonic techniques.
PKD - the DNA test
By DNA testing the mutation can be shown directly. The testing is carried out by state of the art laboratory methods and therefore provides a very high accuracy. In general DNA tests can be done at any age.
The test can be applied to Persian and Persian related cats, which were cross bred to Persians. With this test we can diagnose the reported mutation, but by no means we can report on the presence/absence of the disease (especially in breeds where the correlation of PKD disease and the cited mutation is not proven). The results that are transmitted contain the information on presence/absence of the C to A mutation in the PKD 1 gene exon 29 in the sample of the cat examined. We want to point out that there is still a small possibility of other mutations causing PKD which are not identified so far.
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Price
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£ 48.00 (including VAT)
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