LABOKLIN (UK)| Genetic Diseases | Horses| SCID (Severe Combined Immunodeficiency)

SCID (Severe Combined Immunodeficiency)

Test number: 8039 (this test number replaces the old 8001HGD)
Gene: SCID
Price: £ 48.00 (including VAT)

Breed

Arabian .

The Disease

Severe Combined Immunodeficiency of Arabian foals is a fatal disease caused by the lack of B- and T-lymphocytes. It is estimated that 2-3% of Arabian foals have SCID. This would suggest that 25% of Arabian horses carry the defect gene.

Trait of Inheritance

Severe Combined Immunodeficiency is an inherited autosomal recessive trait. This means that a horse can be genetically clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected horses is the key to controlling this disease.

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.
It is very unlikely that the horse will develop SCID (Severe Combined Immunodeficiency). The horse will never pass the mutation to its offspring, and therefore it can be bred to any other horse.

Carrier

Genotype: N / SCID [ Heterozygous ]

The horse carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the horse will develop SCID (Severe Combined Immunodeficiency) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear horses.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: SCID / SCID [ Homozygous mutant ]

The horse carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
Affected horses usually die before reaching the breeding age.
The horse will develop SCID (Severe Combined Immunodeficiency) and will pass the mutant gene to its entire offspring

Description

This is a mutation-based gene test, which offers many advantages over other methods

The genetic defect leading to the disease has been identified. By DNA testing the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear horses, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.

Sample Requirements

Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.

Turnaround

2 - 3 weeks

Price

£ 48.00 (including VAT)