|
|
Congenital Myasthenic Syndrome (CMS)
|
|
|
|
Breeds
|
Devon Rex
,
Sphynx
.
|
|
|
The Disease |
Congenital Myasthenic Syndrome (CMS) is a genetic disorder that results in congenital muscle weakness in Devon Rex and Sphynx breed cats.
The disease is caused by a an autosomal receissive mutation in the COLQ gene.
|
|
|
|
Clinical Signs |
Clinical symptoms include generalized muscle weakness, particularly following exertion, stress or excitement. Affected cats often exhibit the “dog-begging” or “chipmunk” position, usually with the front legs resting on an object. Affected cats unable to resist the effect of the disease by asphyxiation due to choking on food or aspiration pneumonia by two years of age. Signs of the disease can be seen as early as 3 weeks of age and progress slowly but occasionally do become static.
|
|
|
Trait of Inheritance |
Autosomal Recessive
|
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
|
|
Dam
|
|
Offspring
|
|
|
|
|
|
clear
|
 |
clear
|
 |
100% clear
|
|
|
|
|
|
clear
|
 |
carrier
|
 |
50% clear + 50%
carriers
|
|
|
|
|
|
clear
|
 |
affected
|
 |
100% carriers
|
|
|
|
|
|
carrier
|
 |
clear
|
 |
50% clear + 50%
carriers
|
|
|
|
|
|
carrier
|
 |
carrier
|
 |
25% clear + 25% affected
+ 50% carriers
|
|
|
|
|
|
carrier
|
 |
affected
|
 |
50% carriers + 50%
affected
|
|
|
|
|
|
affected
|
 |
clear
|
 |
100% carriers
|
|
|
|
|
|
affected
|
 |
carrier
|
 |
50% carriers + 50%
affected
|
|
|
|
|
|
affected
|
 |
affected
|
 |
100% affected
|
Clear
Genotype: N / N [ Homozygous normal ]
The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Congenital Myasthenic Syndrome (CMS). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.
Carrier
Genotype: N / CMS [ Heterozygous ]
The cat carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the cat will develop Congenital Myasthenic Syndrome (CMS) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear cats. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: CMS / CMS [ Homozygous mutant ]
The cat carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Congenital Myasthenic Syndrome (CMS) and will pass the mutant gene to its entire offspring
|
|
|
Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
|
|
|
|
Price
|
£ 48.00 (including VAT)
|
|
|
 |
To order:
-
Download
Order Form from this link 
-
Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
|
|
|
|
|
|