prices in Pound
 
  Home
  News and offers
  Genetic Diseases
Dogs
Cats
Horses
Cattle
Pigs
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Organs / Parameters
  Downloads & Order
  Order Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS
  facebook
 
  **NEW**



Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Mycobacterium Avium Complex ( MAC ) sensitivity in Miniature Schnauzer
new test: Chondrodystrophy (CDDY with IVDD Risk) and Chondrodysplasia (CDPA) in many breeds ...
new test: Lafora Disease (LAF)/ Myoclonic Epilepsy in Basset Hound, Beagle and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Sensory Neuropathy in Border Collie
• Neuroaxonal Dystrophy ( NAD ) in Papillon


Bengal Progressive Retinal Atrophy (PRA-b) *

Test number: 8331

PRA-b

Breed
Bengal .
The Disease
Bengal Progressive Retinal Atrophy (PRA-b) is an inherited eye disease affecting the Bengal cat. The disease is characterised by progressive blindness that starts around the age of 7 weeks and slowly progresses until the cat has very compromised vision around the age of two years. The disease develps at different rates in the different cats. The pupil in affected cats is more dilated compared to cats with normal vision. Affected cats tend to carry their whiskers forward. Blind cats tend to have more difficulty at night, sometimes becoming more vocal and more attached to their owners.

The trait of inheritance is autosomal recessive which means that the disease can affect both male and female cats and that a cat can only develop the disease if it inherits two copies of the mutation one from the mother and one from the father. Carries do not develp the disease but they can pass the mutation to offspring and therefore they should only be bred to clear cats. DNA testing enables breeders to breed healthy kittens.

The test is offered in cooperation with the Veterinary Genetic Laboratory at the University of California.

Trait of Inheritance
Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

It is very unlikely that the cat will develop Bengal Progressive Retinal Atrophy (PRA-b) *. The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

 

Carrier

Genotype: N / PRA-b [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cat will develop Bengal Progressive Retinal Atrophy (PRA-b) * but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cats.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: PRA-b / PRA-b [ Homozygous mutant ]

 

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cat is likely to develop Bengal Progressive Retinal Atrophy (PRA-b) * and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
3-4 weeks
Price
£ 60.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
HCM 1 (Hypertrophic cardiomyopathy ) Mutation Meurs (G-- > C) A31P  
Autoimmune Lymphoproliferative Syndrome (ALPS)  
HCM (Hypertrophic Cardiomyopathy)  
PKD (Feline Polycystic Kidney Disease)  
PK Deficiency (Pyruvate Kinase Deficiency)  
rdAc-PRA (Progressive Retinal Atrophy )  
Genetic Blood groups in cats  
SMA (Spinal Muscular Atrophy )  
Serological Evaluation of blood Groups  
Hypokalemia / Familial Episodic Hypokalaemic Polymyopathy (BHK)  
Head Defect (BHD) *  
Alpha-Mannosidosis (AMD)  
Congenital Myasthenic Syndrome (CMS)  
Gangliosidosis GM1  
Gangliosidosis GM2  
Gangliosidosis GM2  
Mucopolysaccharidosis Type VI (MPS VI)  
Mucopolysaccharidosis type VII (MPS VII)  
Myotonia Congenita (Fainting Goat)  
pd - Progressive Retinal Atrophy (pd-PRA)  
Progressive Retinal Atrophy (rdy-PRA)  
HCM1 + PK Deficiency + SMA  
Hypotrichosis and Short Life Expectancy  
Special Offer: HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups  
Osteochondrodysplasia (Scottish Fold Osteodystrophy)  
Primary Congenital Glaucoma (PCG)  
Cystinuria (Feline Cystinuria) (CY)  
Glycogen Storage Disease ( GSD ) Type IV  

 
 
Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Organs / Parameters  |   About us  |   Contact Us
LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066