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Spanish Water Dog DNA bundle Test number: 8287

1 ) Brachyury (Bobtail Gene / Short Tail)

Breeds

Australian Shepherd , Australian Stumpy tail cattle Dog , Austrian Pinscher , Bourbonnais Pointer , Bouvier des Ardennes , Brazilian Terrier , Brittany Spaniel , Croatian Sheepdog , Danish Farm Dog , Jack Russell Terrier , Karelian Bear Dog , Mudi , Polish Lowland sheepdog , Pyrenean Shepherd , Savoy Sheepdog , Schipperke , Spanish Water Dog , Spanish Waterdog , Swedish Farm Dog , Swedish Vallhund , Welsh Corgi .

Description

this test enables you to identify if a dog is docked or has a natural short tail. This conditioned is caused by the Brachyury mutation, the trait of inheritance is autosomal dominant which means that dogs who carry one or two copies of the mutation will have a natural short tail. Dogs with two copies of the normal gene will have normal tail.

Possible results:

Normal: The dog have two copies of the normal gene and will have a normal tail. Heterozygous: The dog carries one copy of the normal gene and one copy of the mutant gene, the dog has a natural short tail. Heterozygous dogs can pass the mutation to their offspring with a probbility of 50%.

Homozygous for the mutation: the dog carries two copy of the mutant gene and has a natural short tail. The dog will pass the mutation to its entire offspring who will all have natural short tail.

In six breed additional studied there is no correlation between the analysed mutation and a short tail: Boston Terrier, English Bulldog, King Charles Spaniel, Miniature Schnauzer, Parson Russell Terrier, Rottweiler

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .

Turnaround

2 - 3 weeks

2 ) Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)

Breeds

Airedale Terrier , Alaskan Malamute , All Dog Breeds , American Eskimo , Bernese Mountain Dog , Bloodhound , Borzoi (Russian Wolfhound) , Boxer , British Timber Dog , Cavalier King Charles Spaniel , Canaan Dog , Cardigan Welsh Corgi , Chesapeake Bay Retriever , Fox Terrier , French Bull Dog , German Shepherd , Glen Of Imaal Terrier , Golden Retriever , Pyrenean Mountain Dog (Great Pyrenees) , Hovawart , Pumi ( Hungarian Pumi / Pumik ) , Jack Russell Terrier , Kerry Blue Terrier , Labrador Retriever , Lakeland Terrier , Northern Inuit , Nova Scotia Duck tolling Retriever ( NSDTR ) , Pembroke Welsh Corgi , Poodle , Pug , Rhodesian Ridgeback , Rough Collie , Soft Coated Wheaten Terrier , Shetland Sheepdog (Sheltie) , Smooth Collie , Utonagan , Wire Fox Terrier .

Kennel Club

This test is part of the Official UK Kennel Club DNA Testing Scheme in Chesapeake Bay Retriever , French Bull Dog , German Shepherd , Nova Scotia Duck tolling Retriever ( NSDTR ) , Rough Collie , and Smooth Collie.

The Disease

Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. As of July 15, 2008 the mutated gene responsible for DM has been found present in 43 breeds including German Shepherds, Boxers, Chesapeake Bay Retrievers, Rhodesian Ridgebacks, and both breeds of Welsh Corgis. The disease is chronic and progressive, and resulting in paralysis.

Clinical Signs

Degenerative myelopathy initially affects the back legs and causes muscle weakness and loss, and lack of coordination. These cause a staggering effect that may appear to be arthritis. The dog may drag one or both rear paws when it walks. This dragging can cause the nails of one foot to be worn down. The condition may lead to extensive paralysis of the back legs. As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking. If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy. Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia. Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive up to three years

Trait of Inheritance

Tow alleles are invloved in Degenerative Myelopathy, A and G, therefore a test result can be A/A, A/G, or G/G.

Mode of inheritance is autosomal recessive with variable penetrance;

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy

Carrier

Genotype: N / DM (Exon 2) [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will show signs of the Degenerative Myelopathy

Affected

Genotype: DM (Exon 2) / DM (Exon 2) [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog may or may not show signs of the disease

Description

Please note that Exon 2 can be found in all dog breeds, there is another DM mutation in Exon 1 which can only be found in Bernese Mountain Dog, click here for more information.

For bernese Mountain Dog we have a special offer for both Exon 1 and Exon 2 at reduced price, click here for more details.

Sample Requirements

Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube Buccal swabs or 0.5 - 1 ml blood in EDTA Blood Tube .

Turnaround

1 - 2 weeks

3 ) Neuroaxonal Dystrophy ( NAD )

Breeds

Papillon , Rottweiler , Spanish Water Dog .

Kennel Club

This test is part of the Official UK Kennel Club DNA Testing Scheme in Papillon , and Spanish Water Dog.

The Disease

Neuroaxonal Dystrophy in Spanish Water Dogs is an uncharacterized juvenile-onset genetic disorder that affect Spanish Water Dogs. Affected dogs exhibits various neurological deficits including gait abnormalities and behavioral deficits.

Symptoms include slowly progressing neurological signs starting between six and eleven months of age. Owners of affected dogs reported gait abnormalities, behavioral changes (dullness, nervousness, vocalization) and incontinence alone or in combination with uncontrolled defecation. Mild head tilt, generalized mild cerebellar ataxia with hypermetria of the thoracic limbs and absent to depressed patellar reflexed. Additionally, affected dogs displayed varying degrees of compulsory pacing, proprioceptive deficits, decreased menace, visual deficits, positional nystagmus and decreased muscle tone.

Trait of Inheritance

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Neuroaxonal Dystrophy ( NAD ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

Carrier

Genotype: N / NAD [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Neuroaxonal Dystrophy ( NAD ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: NAD / NAD [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Neuroaxonal Dystrophy ( NAD ) and will pass the mutant gene to its entire offspring

Description

In Spanish Water dog the disease is caused by a mutation in the TECPR2 gene.

In Papillon, the disease is caused by a mutation in the PLA2G6 gene.

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .

Turnaround

2 - 3 weeks

4 ) Progressive Retinal Atrophy (prcd-PRA) Option 1: (8094P / 8127)

Kennel Club: results of this test is accepted by the Kennel Club

Breeds

American Cocker Spaniel , American Eskimo , Australian cattle dog , Australian Shepherd , Australian Stumpy Tail Cattle Dog , Australian Stumpy tail cattle Dog , Barbet (French Water Dog) , Bearded Collie , Bolognese , Bolonka Zwetna , Chesapeake Bay Retriever , Chihuahua , Chinese Crested , Cockapoo (English) , Cockapoo (American) , Cocker Spaniel , Dwarf poodle , English Cocker Spaniel , English shepherd , Entlebuch Mountain dog , Finnish Lapphund , German Spitz , Giant Schnauzer , Golden Retriever , Jack Russell Terrier , Karelian Bear Dog , Kuvasz , Labradoodle , Labrador Retriever , Lagotto Romagnolo , Lapponian Herder , Markiesje , Miniature Poodle , Miniature American Shepherd , Norwegian Elkhound , Nova Scotia Duck tolling Retriever ( NSDTR ) , Parson Russell Terrier (PRT) , Poodle , Portuguese Waterdog , Schipperke , Australian Silky Terrier , Spanish Water Dog , Standard Poodle , Swedish Lapp Hund , Toy Poodle , Waeller (Wäller) , Yorkshire Terrier .

Kennel Club

This test is part of the Official UK Kennel Club DNA Testing Scheme in Australian cattle dog , Australian Shepherd , Chesapeake Bay Retriever , Chinese Crested , Cocker Spaniel , English Cocker Spaniel , Entlebuch Mountain dog , Finnish Lapphund , Giant Schnauzer , Labrador Retriever , Miniature Poodle , Norwegian Elkhound , Nova Scotia Duck tolling Retriever ( NSDTR ) , Portuguese Waterdog , Spanish Water Dog , Standard Poodle , and Toy Poodle.

The Disease

Progressive retinal atrophy (PRA) as an inherited disease occurs in many dog breeds and also in different forms. The form of progressive rod-cone degeneration (prcd-PRA) is a photoreceptor degeneration in dogs with varying ages of onset. This genetic disorder causes the degeneration of retinal cells in the eye: firstly, rod cells are affected, thus leading to progressive night blindness. Secondly, degeneration of the cone cells results in complete blindness of the dog, even in full light situations during the day.

Age of onset of clinical symptoms is typically in early adolescence or early adulthood. However, the onset of the disease may vary among different dog breeds.

Since diagnosis of retinal diseases in dogs may prove difficult, the genetic test on prcd-PRA helps to diagnose a specific disease and is also a useful tool for breeders to eliminate the mutated gene from the dog population.

Trait of Inheritance

The mutation in the PRCD gene which has been suggested to cause prcd-PRA has recently been published by the group of Gustavo D. Aguirre at the University of Pennsylvania, USA, and could be found in several dog breeds. Prcd-PRA is inherited as an autosomal recessive trait. So there are three conditions a dog can be: it can be clear (genotype N/N or homozygous normal) meaning that it does not carry the mutation and will not develop the prcd-form of PRA. Since it also cannot pass the mutation onto its offspring, it can be mated to any other dog.

A dog which has one copy of the PRCD gene with the mutation and one copy without the mutation is called a carrier or heterozygous (genotype N/PRA); while it will not be affected by prcd-PRA, it can pass the mutation onto its offspring and should therefore only be mated to clear dogs. Dogs that develop this form of PRA have two PRCD gene copies with the mutation (genotype PRA/PRA or homozygous affected); they will always pass the mutated gene onto their offspring and should also be mated only to clear dogs..

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy (prcd-PRA) Option 1: (8094P / 8127). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

Carrier

Genotype: N / PRA [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Progressive Retinal Atrophy (prcd-PRA) Option 1: (8094P / 8127) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: PRA / PRA [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Progressive Retinal Atrophy (prcd-PRA) Option 1: (8094P / 8127) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .

Turnaround

2 - 3 weeks

5 ) Congenital Hypothyreosis / hypothyroidism ( CHG )

Breeds

Fox Terrier , French Bull Dog , Rat Terrier , Spanish Water Dog , Tenterfield Terrier .

Kennel Club

This test is part of the Official UK Kennel Club DNA Testing Scheme in Spanish Water Dog.

The Disease

Hypothyreosis stands for all different kind of thyroid gland sub-function, independent of the origin. A lot of symptoms relate to Hypothyreosis including general symptoms like lethargy or increase in weight, as well as problems concerning heart, skin and nerves. In Spanish Water Dogs sub-function of the thyroid gland can originate from a genetic source. Affected dogs have a very short lifespan and normally die as puppies.

Trait of Inheritance

Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Congenital Hypothyreosis / hypothyroidism ( CHG ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

Carrier

Genotype: N / CHG [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Congenital Hypothyreosis / hypothyroidism ( CHG ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: CHG / CHG [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Congenital Hypothyreosis / hypothyroidism ( CHG ) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .

Turnaround

2 - 3 weeks

Price for the above 5 tests

£ 156.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:

Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF

Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

See Also:
	Copper Toxicosis (Copper Storage Disease )
	Progressive Retinal Atrophy (Dominant PRA)
	Globoid Cell Leukodystrophy (Krabbe Disease)
	CSNB (Congenital Stationary Night Blindness)
	CLAD (Canine Leukocyte Adhesion Deficiency)
	Cystinuria
	von Willebrand disease Type II (vWD II)
	PK Deficiency (Pyruvate Kinase Deficiency)
	Fucosidosis
	PFK Deficiency (Phosphofructokinase deficiency)
	Myotonia Congenita
	MH (Malignant Hyperthermia)
	X-Linked Severe Combined Immunodeficiency (X-SCID)
	GM1-Gangliosidosis
	Narcolepsy
	Muscular Dystrophy (MD)
	MPS ( Mucopolysaccharidosis type VII)
	Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM)
	Canine Cyclic Neutropenia (Gray Collie Syndrome)
	Progressive Retinal Atrophy (cord1- PRA / crd4 PRA)
	L-2-HGA ( L- 2 - hydroxyglutaric aciduria )
	von Willebrand disease Type I (vWD I)
	von Willebrand disease Type III (vWD III)
	Neuronal Ceroid Lipofuscinosis ( CL / NCL )
	Trapped Neutrophil Syndrome ( TNS )
	Progressive Retinal Atrophy (crd PRA)
	PDP 1 Deficiency (Pyruvate Dehydrogenase Phosphatase 1 Deficiency)
	Factor VII Deficiency
	Progressive Retinal Atrophy (rcd1 PRA)
	Progressive Retinal Atrophy (rcd1a PRA)
	Juvenile Brain Disease ( JBD ) / Juvenile Encephalopathy ( Epilepsy )
	Microphthalmia ( RBP4 )
	French Bulldog DNA bundle
	Leonberger DNA bundle
	Lethal Acrodematitis ( LAD )
	BRAF Mutation ( transitional cell carcinoma )
	MDR1 Gene Varian / Ivermectin Sensitivity *
	Exercise Induced Collapse ( EIC )
	Dwarfism (Pituitary Dwarfism / Hypopituitarism)
	Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
	Greyhound Neuropathy (Hereditary Neuropathy)
	Brittle Bone Disease (Osteogenesis Imperfecta)
	Glycogen Storage Disease (GSDllla)
	Hereditary Cataract (HSF4)
	Neonatal encephalopathy (NE / NEWS)
	Haemophilia B (factor IX deficiency)
	JEB (Junctional Epidermolysis bullosa)
	Primary Lens Luxation (PLL)
	Brachyury (Bobtail Gene / Short Tail)
	Familial Nephropathy (FN) / Hereditary Nephropathy *
	Startle Disease (SD) / Hyperekplexia
	Familial Nephropathy (FN) / Hereditary Nephropathy
	Myostatin Mutation ("Bully" Whippet)/ Double Muscling
	Hereditary Nephritis / Samoyed Hereditary Glomerulopathy
	Episodic Falling in Cavalier King Charles Spaniel (EF)
	Dry Eye and Curly Coat syndrome (CCS)
	CKCS Pack A: Episodic Falling + Dry Eye Curly Coat syndrome
	Haemophilia A (factor VIII deficiency)
	Congenital Hypothyreosis / hypothyroidism ( CHG )
	Hereditary Nasal Parakeratosis (HNPK)
	Juvenile Epilepsy (JE)
	Musladin-Lueke syndrome (MLS)
	Ichthyosis *
	Neonatal Cortical Cerebellar Abiotrophy (NCCD)
	Dwarfism (Skeletal Dysplasia 2 / SD2 )
	Primary Open Angle Glaucoma (POAG)
	Progressive Retinal Atrophy (generalized PRA)
	Progressive Retinal Atrophy (GR-PRA1)
	Progressive retinal atrophy ( rcd4-PRA) / LOPRA
	Alaskan Malamute Polyneuropathy (AMPN / IPAM / HPAM)
	Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME)
	Polycystic Kidney Disease (PKD)
	Pompe's Disease (Glycogen Storage Disease type II / GSDII)
	Primary ciliary dyskinesia (PCD)
	Protein Losing Nephropathy (PLN)
	Late Onset Ataxia (LOA)
	Cobalamin Malabsorption (Imerslund-Gräsbeck syndrome (IGS))
	Collie Eye Anomaly (CEA) / Choroidal Hypoplasia (CH) Option 2 Optigen*
	Retinal Dysplasia (RD) / Oculo Skeletal Dysplasia (OSD)*
	Spinocerebellar ataxia (SCA)
	Cystinuria (Dominant)
	pap-PRA1 (Progressive Retinal Atrophy)
	Progressive Retinal Atrophy (BAS PRA)
	CMSD (Canine Multiple System Degeneration)
	Hereditary Cataract (HSF4) *
	Special offer 4: Juvenile Epilepsy + Furnishing + LSD
	Progressive Retinal Atrophy (prcd-PRA) Option 2: Optigen (8094X)
	Progressive Retinal Atrophy (prcd-PRA) Option 1: (8094P / 8127)
	Thrombopathia (Thrombopathy)
	Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet)
	Degenerative Myelopathy / degenerative radiculomyelopathy) DM (Exon 1)
	Degenerative Myelopathy / degenerative radiculomyelopathy) DM (Exon 1 + Exon 2)
	Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS)
	Hypomyelination (Shaking Puppy Syndrome) SPS
	Type A PRA * Optigen)
	JRT and PRT Pack A: Late Onset Ataxia (LOA) + Spinocerebellar Attaxia (SCA)
	JRT and PRT Pack B:Late Onset Ataxia (LOA) + Spinocerebellar Attaxia (SCA) + PLL + JBD
	Leonberger Polyneuropathy 1 ( LPN1)
	Hereditary Ataxia (HA)
	Finnish Hound Ataxia / Cerebellar Ataxia (FHA / CAFH)
	Dandy-Walker-Like Malformation (DWLM)
	Persistent Müllerian duct syndrome (PMDS)
	Cone Degeneration (CD) by OptiGen *
	Fanconi Syndrome (FS)
	Lagotto Storage Disease (LSD)
	Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)
	Progressive Retinal Atrophy (CNGA1 PRA)
	Achromatopsia (day blindness) / ACHM
	Progressive Retinal Atrophy (GR-PRA2)
	Unspecified test
	Postoperative Hemorrhage (P2Y12 / P2RY12)
	Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT)
	Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency
	C3 Deficiency (Complement Component 3 deficiency)
	Congenital Myasthenic Syndrome (CMS)
	Bardet Biedl Syndrome (BBS)
	GM2 Gangliosidosis Variant 0 (Sandhoff Disease)
	Macrothrombocytopenia ( MTC-D )
	Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
	Vitamin D-dependent Rickets (HVDRR)
	Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH)
	X-linked Myotubular Myopathy (XLMTM)
	Collie Eye Anomaly (CEA) / Choroidal Hypoplasia (CH) Option 1*
	Macrothrombocytopenia ( MTC- R )
	Muscular Dystrophy (MDL)
	Mucopolysaccharidosis type IIIa (MPS IIIA)
	Neuroaxonal Dystrophy ( NAD )
	Progressive Retinal Atrophy (rcd2-PRA) Option 1 by Laboklin
	Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) )
	May-Hegglin Anomaly (MHA)
	Alaskan Husky Encephalopathy (AHE)
	Cerebral Dysfunction (CDF)
	Dwarfism ( Chondrodysplasia )
	Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis)
	Hemorrhagic Diathesis / Bleeding Diathesis (Canine Scott Syndrom)
	Glycogen storage disease type Ia (GSD Ia) / VON Grieke Disease
	Gallbladder Mucoceles
	Primary Hyperoxaluria type I (PH I)
	Hyperuricosuria / Urate Stones (HUU, SLC)
	Severe Combined Immunodeficiency (SCID)
	Leukocyte Adhesion Deficiency type III (LAD III)
	Cleft Lip / Palate and Syndactyly (CLPS)
	Progressive Retinal Atrophy (crd1 PRA)
	Progressive Retinal Atrophy (CRD2 PRA)
	Spondylocostal Dysostosis (Comma Defect)
	Canine Multi-Focal Retinopathy (CMR)
	Craniomandibular Osteopathy (CMO)
	Retinal Dysplasia (RD) / Oculo Skeletal Dysplasia (OSD)*
	Special Offer: DM (Exon 2) + MDR1
	Special Offer Chinese Crested: PLL + prcd PRA Option 1 + rcd3 PRA + DM Exon 2
	Warbung Micro Syndrome 1 (WARBM1)
	Raine Syndrome
	van den Ende-Gupta Syndrom (VDEGS)
	Lundehund-Syndrome ( Lymphagetasia )
	Obesity / Adiposity ( ADI )
	Alexander Disease (AxD) / Leukodystrophy
	Spinal Dysraphism / Neural Tube Defects ( NTD )
	Spongy Degeneration with Cerebellar Ataxia ( SDCA1 )
	XL - PRA (Progressive retinal Atrophy)
	Nemaline Myopathy (NM)
	Beagle DNA Bundle : IGS + Factor VII + MLS + NCCD + Osteogenesis imperfecta + PK + POAG
	Poodle DNA Bundle: DM exon2 + rcd4 PRA + NE + prcd-PRA option 1 + vWD1
	Golden Retriever DNA bundle: GR-PRA1 + GR-PRA2 + Ichthyosis + prcd-PRA option 1 + Muscular Dystrophy (MD)
	Pug Special Offer: DM Exon2 + MH + PDE / NME + PK + PLL
	Aussie DNA bundle: CEA option * + DM exon2 + HSF4 + MDR1 + MH + NCL + prcd-PRA Option 1*
	Collie DNA Bundle: CEA Option 1 + DM exon2 + HUU (SLC) + MDR1 + rcd2-PRA
	Border Collie DNA Bundle: CEA Option 1 + IGS + MDR1 + Raine + SN + NCL + TNS + GGD
	Pack A: CNM + DM exon2 + EIC + HNPK + OSD option 1 + prcd-PRA option 1 + SD2
	Pack B: AxD + Cystinuria + Narcolepsy + Obesity + PK + SLC + XL-MTM
	Ichthyosis
	Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia
	Juvenile Myoclonic Epilepsy ( JME )
	Paroxysmal Dyskinesia ( PxD )
	Spongy Degeneration with Cerebellar Ataxia ( SDCA2 )
	Belgian Shepherd Special Offer : SDCA1 + SDCA2
	Sensory Neuropathy ( SN )
	Acute Respiratory Distress Syndrome ( ARDS )
	POAG / PLL Primary Open Angle Glaucoma (POAG) and Primary Lens Luxation (PLL)
	Shar Pei auto-inflammatory disease (SPAID)
	Dystrophic Epidermolysis Bullosa (DEB)
	Doberman DNA bundle (DM2 + vWDI + Narcolepsy + B Locus + D Locus)
	Landseer DNA bundle (Cystinuria + DM2 + SLC + MD + Thrombopathia)
	Rhodesian Ridgeback DNA Bundle (DM2 + Haemophilia B + B Locus + JME + D Locus)
	Rottweiler DNA bundle ( DM2 , SLC , JLPP , CL1 , XL - MTM )
	Leonberger Polyneuropathy 2 ( LPN2 )
	Hereditary Nasal Parakeratosis (HNPK)
	Subacute Necrotizing Encephalopathy (SNE)
	ISDS Exclusive Border Collie DNA Bundle: CEA 1* + IGS + SN + TNS
	Acral Mutilation Syndrome ( AMS )
	Lafora Disease (LAF / LD) / Myoclonic Epilepsy
	Shetland DNA Bundle: CEA option 1 + DM Exon 2 + vWD Type III + MDR1 + CNGA1-PRA
	CKCS Pack B: DM Exon2 + Episodic Falling + DryEye + MD + MTC
	Progressive Retinal Atrophy (rcd3 PRA)
	Old English Sheepdog (Bobtail) DNA bundle: DM Exon2 + EIC + HA + MDR1 + PCD
	German Shepherd and Wolfdog DNA Bundle
	Glaucoma and Goniodysgenesis (GGD)
	Leukoencephalomyelopathy ( LEMP )
	Hereditary Deafness ( PTPRQ )
	Type B PRA * (Optigen)
	Neuronal Ceroid Lipofuscinosis Combi in ACD & AUSSIE ( NCL Combi )
	Chondrodystrophy (CDDY with IVDD Risk) and Chondrodysplasia (CDPA)
	Mycobacterium Avium Complex ( MAC ) sensitivity
	Australian Cattle Dog bundle (DM Exon2 + NCL + PLL + prcd-PRA (partnerlab) + rcd4-PRA)
	Dachshund DNA bundle (IVDD-risk + Osteogenesis imperfecta + NCL + cord1-PRA + crd-PRA)
	English Springer Spaniel DNA bundle (AMS + FN + SPS + Fucosidosis + PFKD + cord1-PRA )
	Welsh Corgi DNA bundle (Brachyuria + IVDD-risk + DM exon2 + rcd3-PRA + vWD1)
	Cocker Spaniel DNA bundle (AMS + FN + prcd PRA option 1)
	Leukoencephalopathy ( LEP )
	Larynx / Laryngeal Paralysis ( LP )
	Dilated Cardiomyopathy ( DCM )
	Mucopolysaccharidosis type IIIb ( MPS3b )
	Renal dysplasia and hepatic fibrosis ( RDHN )
	Stargardt disease ( STGD )
	NECAP-1 Progressive Retinal Atrophy ( NECAP1 PRA / NECAP PRA5)
	SCWT DNA bundle (DM + PLN + PxD + RBP4 + SLC )
	Inflammatory Pulmonary Disease ( IPD )
	Hypophosphatasia ( HPP )
	Upper Airway Syndrome ( UAS )
	Oculoskeletal Dysplasia ( OSD 3 )
	Shiba Inu DNA bundle (GM1 , GM2 , A Locus and E Locus)