Lethal Acrodematitis ( LAD ) is an inherited disease affecting the Bull Terriers and Miniature Bull Terriers breeds. The disease is characterised by poor growth, immune deficiency, and skin lesions, especially at the paws.Symptoms includ erythema and adherent scales on the the feet, elbows, hocks and muzzle. Hyperkeratosis of the foot pads is also seen. Immunodeficiency increases susceptibility to microbial infections including skin disease of the face and feet. Signs include stunting, splayed digits and eating difficulties. In older dogs, paronychia, nail disease and hyperkeratosis of the footpads develops, becoming severe in dogs over six months of age.
Puppies suffering from this condition have a greatly reduced lifespan due to infection, and they are often euthanized when the condition becomes very severe and painful.
The disease is caused by a mutation in the MKLN1 gene and a DNA test is now available at Laboklin.