Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is a genetic disease that affects the nerves. In affected dogs, JLPP starts with the longest nerves in the body, one of the longest nerves is the one that supplies the muscles of the voice box (larynx) leading to muscle weakness and laryngeal paralysis as the first symptom. The vocal folds vibrate noisily and can obstruct the flow of air into the lungs when the dog is exercised or when it is hot. The dog may also choke on their food or water or regurgitate, and this can cause pneumonia.
The disease then progresses to the next longest nerves which supply the muscles of the back legs resulting in difficulty getting up and wobbly gait, the hind limbs are followed by the front limbs.
Other symptoms include abnormalities in eye development.
Symptoms typically start after weaning age.