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Episodic Falling + Dry Eye Curly Coat syndrome

Test number: 8229D

1 ) Episodic Falling in Cavalier King Charles Spaniel (EF)
Breed
Cavalier King Charles Spaniel .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
The Disease
Episodic Falling is a genetic neurological disorder found in Cavalier King Charles Spaniels. Episodes are usually triggered by exercise, stress or excitement and are characterised by increased muscle tone and stiffness throughout the thoracic and pelvic limbs resulting in a characteristic 'deer-stalking' position and or collapse. The onset of symptoms is usually between fourteen weeks and four years of age but may appear at any age. Clinical symptoms vary in severity ranging from mild, occasional falling to freezing or seizure-like episodes lasting hours. Severity of the episodes can increase or decrease as the dog gets older. There is no standard pattern to the attacks.

The disease is also known as Exercise-Induced Paroxysmal Hypertonicity, Falling Cavaliers and Collapsing Cavalier Syndrome.

Prof. Dr. Robert Harvey of the London School of Pharmacy has recently identified the underlying genetic defect causing Episodic Falling in Cavalier King Charles Spaniels. LABOKLIN have recently implemented the genetic test for this disease under licence from the London School of Pharmacy. This test is currently patented within Europe, with Laboklin as the testing laboratory.

Trait of Inheritance
Episodic Falling is inherited as a autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Episodic Falling in Cavalier King Charles Spaniel (EF) and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / EF [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop Episodic Falling in Cavalier King Charles Spaniel (EF) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: EF / EF [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF) and will pass the mutant gene to its entire offspring
Description

SPECIAL OFFER

TWO TESTS FOR THE PRICE OF ONE
Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT) FOR BOTH TESTS.

Click here for details OFFER

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
1 - 2 weeks

We will run this test 2 independant times on your sample to ensure that the result is 100% accurate

2 ) Dry Eye and Curly Coat syndrome (CCS)
Breed
Cavalier King Charles Spaniel .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.
Description

SPECIAL OFFER

TWO TESTS FOR THE PRICE OF ONE
Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT) FOR BOTH TESTS.

Click here for details OFFER

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
1 - 2 weeks

We will run this test 2 independant times on your sample to ensure that the result is 100% accurate

Price for the above 2 tests
£ 66.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

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