LABOKLIN (UK)|Genetic Diseases | Dogs| Brittle Bone Disease (Osteogenesis Imperfecta)

Brittle Bone Disease (Osteogenesis Imperfecta)

Breeds

Dachshund , Miniature Long Haired Dachshund , Miniature Smooth Haired Dachshund .

The Disease

Osteogenesis Imperfecta is a generalized, inherited bone defect characterized by extreme fragility of bones and loose joints. The bones can break easily, sometimes they break for no known reason. The long bones are slender and have thin cortices. Calluses and recent fractures may be present. The disease can also cause weak muscles, brittle teeth, curved spine and hearing loss. The cause of the disease is a gene defect that affects how the body makes collagen, a protein that helps make bones strong

Clinical Signs

Clinical signs include pain, spontaneous bone and teeth fractures, loose joints, and reduced bone density on radiography. Primary teeth are extremely thin-walled and brittle Osteogenesis imperfecta can range from mild to severe and symptoms vary from one dog to another.

Trait of Inheritance

Osteogenesis imperfecta Is inherited as a autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait

Sire
Dam Offspring

Clear
x
Clear
>
100% Clear

clear
x
carrier
>
50% Clear + 50% carriers

clear
x
affected
>
100% carriers

carrier
x
Clear
>
50% Clear + 50% carriers

carrier
x
carrier
>
25% clear + 25% affected + 50% carriers

carrier
x
affected
>
50% carriers + 50% affected

affected
x
Clear
>
100% carriers

affected
x
carrier
>
50% carriers + 50% affected

affected
x
affected
>
100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
The dog will never develop Brittle Bone Disease (Osteogenesis Imperfecta) and therefore it can be bred to any other dog.

Carrier

Genotype: N / OI [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
The dog will never develop Brittle Bone Disease (Osteogenesis Imperfecta) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: OI / OI [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog will develop Brittle Bone Disease (Osteogenesis Imperfecta) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

within 7 working days

Price

£ 55.00 (including VAT)

LABOKLIN GmbH & Co. KG

ISO / DIN 17025 Accredited Laboratory

125 Northenden Road, Manchester, M33 3HF