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M Locus * / Merle Gene / Dapple (merle / Cryptic Merle)

Test number: 8188

update
The test can now detect the alleles: M (merle), Mh (Harlquin-merle), Ma (atypic merle), Mc (cryptic merle) and m (non-merle). The new allele found: Mh (Harlquin-merle) will also be detected by the test

Breeds
All Dog Breeds , American Cocker Spaniel , American Staffordshire Terrier , Australian Shepherd , Beauceron , Bergamasco , Bobtail , Border collie , Cardigan Welsh Corgi , Catahoula Leopard Dog , Chihuahua , Dachshund , Great Dane , Hungarian Mudi , Koolie ( Australian Koolie ) , Norwegian Dunker , Old English Sheepdog (Bobtail) , Pomeranian , Pyrenean Shepherd , Rough Collie , Shetland Sheepdog (Sheltie) , Smooth Collie .
Trait of Inheritance
.

Inheritance : AUTOSOMAL DOMINANT trait
Description

The Merle (Dapple) Gene

The merle DNA test can detect the following alleles:

M (merle), Mc (cryptic merle), Ma (atypical merle), Mh (harlequin merle) and m (non-merle).

Merle (M)

The merle allele (M) is known to dilute random parts of the coat colour to a lighter shade such as black to gray or blue, brown to lighter patches. The merled patches have irregular edges and can be anywhere on the head, the body and the legs resulting in the familiar merle coat pattern. Merle can also affect the eyes, the nose and the paw pads.
The Merle (M) allele is dominant to the normal non-merle allele (m) and so a dog with one copy of the merle gene will express the merle pattern and a dog with two copies of the merle is called double merle (double dapple). Double merle is associated with health problems such as deafness and blindness, and also sun sensitivity and skin cancer, and therefore breeders should avoid breeding merle to merle.

Harlequin Merle (Mh)

The Mh allele is similar to the Merle allele but it causes the expression of the harlequin pattern in some Collie type breeds. It is also dominant to the non-merle.

Hidden Merle:

Merle can be hidden which means that you cannot see if the dog is merle or not and therefore you may breed merle to merle and produce double merle puppies without realising. There are two types of hidden merle Invisible merle and Cryptic merle:
Invisible Merle

Invisible merle occurs when the dog actually carries the merle allele (M) but you cannot see it because it is hidden. This happens when the dog’s coat colour is yellow, red, sable, fawn, gold or cream, in this case merle is almost invisible because merle is expressed on eumelanin pigment (black, brown, blue, lilac) but not on pheomelanin pigment, and so if your dog’s coat colour is yellow, red, sable, fawn, gold or cream, it is often very difficult to tell if the dog has merle by looking at it and the only way to find out if your dog has merle is by testing.

Cryptic Merle (Mc)

Cryptic merle (Mc) is a short version of the merle allele with very little merling effect if any. Cryptic merle is not associated with health problems but it is a mutable allele and when the dog is bred it may well expand to regular merle in the puppies and so it should be treated same as regular merle and dogs with cryptic merle should only be bred to dogs with no merle. The Ma allele (Atypical Merle) can also be cryptic hidden (see next paragraph)

Atypical Merle (Ma)

The test can now detect the Atypical Merle (Ma) allele which is a mutable allele that causes the expression of different non-typical and typical merle patterns ranging from dilution to normal merle and even piebald-like patterns. Atypical merle can also be cryptic, in this case it is hidden and not visible but like the cryptic merle, when bred it can expand to full merle and therefore it should be treated as if the dog carries the merle allele and should only be bred to dogs with no merle.

Summary

The test detects : M (merle), Mc (cryptic merle), Ma (atypical merle), Mh (harlequin merle) and m (non-merle). The m allele (non-merle) is recessive to all the other alleles. Double merle is associated with health problems and should be avoided. To avoid having double merle puppies, dogs carrying at least one copy of the M (merle), Mc (cryptic merle), Ma (atypical merle) or Mh (harlequin merle) allele should only be bred to dogs that do not carry any of these alleles ie dogs with two copies of the non-merle (m/m).

 
Further reading
The Merle / Dapple GenePDF file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
Coat Colours: E-Locus E1 (yellow, lemon, red, cream and appricot)  
D Locus D1 + D3 ( Dilution )  
Coat Colours: A-Locus Agouti ( fawn, sable, black and tan/tricolor, recessive black)  
Coat Colours: D-Locus D1 ( Dilution )  
Coat Colours: K- Locus  
Coat Colours: EM-Locus Melanistic Mask Allele (Em), E-Locus  
Curly Coat  
Furnishings and Improper Coat  
Coat Colour EG- Locus (domino, grizzle)  
Coat Colour: EH-locus (sable)  
Coat Colour: S-locus (piebald, spotted white)*  
Hairlessness  
Harlequin  
Saddle Tan  
Coat (hair) Length I  
Coat (hair) Length II  
Panda White Spotting  
C Locus (Albino)  
Coat Colour: D2 - Locus ( Dilution )  
D Locus D1 + D2 ( Dilution )  
Coat Length I + II ( Long or Shor Hair)  
Coat Colours: E-Locus E2 (Red / Yellow)  
Coat Colour DNA bundle: Loci A + B + D1 + E1 + I + K + S  
I - Locus (phaeomelanin intensity)  
Coat Colour: D3 - Locus ( Dilution )  
Coat Colour: B Locus (Brown Coat Colour)  

 
 
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125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066