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Exercise Induced Collapse ( EIC )
NEW EUROPEAN EXCLUSIVE LICENSE 10/12/2008
We are pleased to announce that LABOKLIN has now an Exclusive License to offer the EIC DNA test (Exercise Induced Collapse) in Labrador Retriever in Europe.

Breeds
Chesapeake Bay Retriever , German Wirehaired Pointer , Labrador Retriever , Old English Sheepdog (Bobtail) , Pembroke Welsh Corgi , Curly Coated Retriever , Boykin Spaniel .
The Disease
Exercise Induced Collapse is an inherited condition that affects Labrador Retriever and related breeds. Affected dogs can endure mild to moderate exercise but after 5 to 20 minutes of heavy exercise with extreme excitement, the dog shows weakness and then collapse. Severely affected dogs may collapse whenever they are exercised to this extend – other dogs only exhibit collapse episodes sporadically.

Signs of EIC are not typically seen until the dog begin intense training. First symptoms are usually noted between 5 months and 3 years of age. However, it is confirmed that some affected dogs did not have collapse episodes until as late as age 10.

Clinical Signs
The first symptom noted during an episode is usually a rocking or forced gait. The rear limbs then become weak and unable to support weight. Many affected dogs will continue to run while dragging their back legs. Some dogs appear uncoordinated, especially in the rear limbs, with a wide-based, long, loose stride rather than the sort stiff strides typically associated with muscle weakness. In some dogs the rear limb collapse progresses to forelimb weakness and occasionally to a total inability to move. Some dogs appear to have a loss of balance and may fall over, particularly as they recover from complete collapse. Most collapsed dogs are totally conscious and alert, still trying to run and retrieve, but as many as 25% of affected dogs will appear stunned or disoriented during the episode.












Trait of Inheritance
EIC follows an autosomal recessive trait of inheritance.








Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

  Dam   Offspring
         
Clear
x
Clear
>
100% Clear
         
clear
x
carrier
>
50%  Clear + 50% carriers
         
clear
x
affected
>
100% carriers
         
carrier
x
Clear
>
50%  Clear + 50% carriers
         
carrier
x
carrier
>
25% clear + 25% affected + 50% carriers
         
carrier
x
affected
>
50% carriers + 50% affected
         
affected
x
Clear
>
100%  carriers
         
affected
x
carrier
>
50% carriers + 50% affected
         
affected
x
affected
>
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Exercise Induced Collapse ( EIC ) and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / EIC [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop Exercise Induced Collapse ( EIC ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: EIC / EIC [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop Exercise Induced Collapse ( EIC ) and will pass the mutant gene to its entire offspring
Description

The the genetic mutation responsible for susceptibility to EIC was identified at the University of Minnesota (EE Patterson, JR Mickelson, KM Minor).

This is a mutation based test that classifies dogs as Clear, Carriers and Affected. Clear and Carrier dogs will not show signs of EIS, however carriers can pass the mutation to their offspring. The test provides reliable information to dog breeders and owners that enable them to control the spread of the mutation in the breed.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
within 1 - 2 weeks
Price
£ 72.50 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
Copper Toxicosis  
Progressive Retinal Atrophy (Dominant PRA)  
Globoid Cell Leukodystrophy (Krabbe Disease)  
CSNB (Congenital Stationary Night Blindness)  
CLAD (Canine Leukocyte Adhesion Deficiency)  
Cystinuria  
von Willebrand disease Type II (vWD II)  
PK Deficiency (Pyruvate Kinase Deficiency)  
Fucosidosis  
PFK Deficiency (Phosphofructokinase deficiency)  
Myotonia Congenita  
MH (Malignant Hyperthermia)  
X-Linked Severe Combined Immunodeficiency (X-SCID)  
GM1-Gangliosidosis  
Narcolepsy  
Muscular Dystrophy (MD)  
MPS ( Mucopolysaccharidosis type VII)  
Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM)  
Canine Cyclic Neutropenia (Gray Collie Syndrome)  
Progressive Retinal Atrophy (cord1- PRA)not recommended for diagnosis  
Progressive Retinal Atrophy (prcd - PRA)  
L-2-HGA ( L- 2 - hydroxyglutaric aciduria )  
von Willebrand disease Type I (vWD I)  
von Willebrand disease Type III (vWD III)  
Neuronal Ceroid Lipofuscinosis ( NCL )  
Trapped Neutrophil Syndrome ( TNS )  
Progressive Retinal Atrophy (crd PRA)  
PDP 1 Deficiency (Pyruvate Dehydrogenase Phosphatase 1 Deficiency)  
Factor VII Deficiency  
Progressive Retinal Atrophy (rcd1 PRA)  
Progressive Retinal Atrophy (rcd3 PRA)  
Progressive Retinal Atrophy (rcd1a PRA)  
MDR1 Gene Defect / Ivermectin Sensitivity *  
Dwarfism (Pituitary Dwarfism / Hypopituitarism)  
Degenerative Myelopathy / degenerative radiculomyelopathy) DM  
Greyhound Neuropathy (Hereditary Neuropathy)  
Brittle Bone Disease (Osteogenesis Imperfecta)  
Glycogen Storage Disease (GSDllla)  
Hereditary Cataract (HSF4)  
Hyperuricosuria / Urate Stones (HUU, SLC)  
Neonatal encephalopathy (NE)  
Haemophilia B (factor IX deficiency)  
JEB (Junctional Epidermolysis bullosa)  
Primary Lens Luxation (PLL)  
Brachyury (Bobtail Gene / Short Tail)  
Familial Nephropathy (FN) / Hereditary Nephropathy *  
Startle Disease (SD) / Hyperekplexia  
Familial Nephropathy (FN) / Hereditary Nephropathy  
Myostatin Mutation ("Bully" Whippet)/ Double Muscling  
Hereditary Nephritis / Samoyed Hereditary Glomerulopathy  
Episodic Falling in Cavalier King Charles Spaniel (EF)  
Dry Eye and Curly Coat syndrome (CCS)  
Episodic Falling + Dry Eye Curly Coat syndrome

LIMITED PERIOD OFFER ONLY £55
FOR BOTH TESTS

 
Haemophilia A (factor VIII deficiency)  
Congenital Hypothyreosis / hypothyroidism (CHG)  
Hereditary Nasal Parakeratosis (HNPK)  
Juvenile epilepsy  
Musladin-Lueke syndrome (MLS)  
Ichthyosis  
Neonatal Cortical Cerebellar Abiotrophy (NCCD)  
Dwarfism (Skeletal Dysplasia 2)  
Primary Open Angle Glaucoma (POAG)  
Progressive Retinal Atrophy (generalized PRA)  
Progressive Retinal Atrophy (GR-PRA1)  
Progressive retinal atrophy ( rcd4-PRA) / LOPRA  
Alaskan Malamute Polyneuropathy (AMPN / IPAM / HPAM)  
Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME)  
Bull Terrier Polycystic Kidney Disease (BTPKD)  
Pompe's Disease (Glycogen Storage Disease type II / GSDII)  
Pompe's Disease (GSDII) AND prcd PRA (Progressive Retinal Atrophy)  
Primary ciliary dyskinesia (PCD)  
Protein Losing Nephropathy (PLN)  
Late Onset Ataxia (LOA)  
Cobalamin Malabsorption (Imerslund-Gräsbeck syndrome (IGS))  
Collie Eye Anomaly (CEA) / Choroidal Hypoplasia (CH) *  
Progressive Retinal Atrophy (rcd2-PRA)*  
Retinal Dysplasia (RD) / Oculo Skeletal Dysplasia (OSD)*  
Spinocerebellar ataxia (SCA) *  
Cystinuria (Labrador Cystinuria)  
Cystinuria IN Australian Cattle Dog  
pap-PRA1 (Progressive Retinal Atrophy)  
Progressive Retinal Atrophy (PRA)  
CMSD (Canine Multiple System Degeneration)  
Hereditary Cataract *  
Special Offer1: DM + MDR1 + MH + D Locus + HUU (SLC) All 5 tests for only £198.50 incl VAT (Save £114.00)  
Special Offer2: MDR1 + DM + MH + D Locus - Great offer £172.50 incl VAT for all the 4 tests. Save £85.00  
Special Offer3: MDR1 + DM - Great Offer only £115 Incl VAT (Save £32.50)  
Special offer 4: Juvenile Epilepsy + Furnishing  
Special offer 5: Collie Eye Anomaly + Hereditary Cataract + MDR1 (Save £57.50)  
Special offer 6: OPTIGEN's prcd PRA + EIC + HNPK + DNA Profile (ONLY £300 incl VAT - Save £87.50)  

 
 
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