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Exercise Induced Collapse ( EIC )

Test number: 8152


We are pleased to announce that LABOKLIN has now an Exclusive License to offer the EIC DNA test (Exercise Induced Collapse) in Labrador Retriever in Europe.

Chesapeake Bay Retriever , German Wirehaired Pointer , Labrador Retriever , Old English Sheepdog (Bobtail) , Pembroke Welsh Corgi , Clumber Spaniel , Cocker Spaniel , Curly Coated Retriever , Boykin Spaniel , Bouvier des Flanders .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Labrador Retriever , and Clumber Spaniel.
The Disease
Exercise Induced Collapse is an inherited condition that affects Labrador Retriever and related breeds. Affected dogs can endure mild to moderate exercise but after 5 to 20 minutes of heavy exercise with extreme excitement, the dog shows weakness and then collapse. Severely affected dogs may collapse whenever they are exercised to this extend – other dogs only exhibit collapse episodes sporadically.

Signs of EIC are not typically seen until the dog begin intense training. First symptoms are usually noted between 5 months and 3 years of age. However, it is confirmed that some affected dogs did not have collapse episodes until as late as age 10.

Clinical Signs
The first symptom noted during an episode is usually a rocking or forced gait. The rear limbs then become weak and unable to support weight. Many affected dogs will continue to run while dragging their back legs. Some dogs appear uncoordinated, especially in the rear limbs, with a wide-based, long, loose stride rather than the sort stiff strides typically associated with muscle weakness. In some dogs the rear limb collapse progresses to forelimb weakness and occasionally to a total inability to move. Some dogs appear to have a loss of balance and may fall over, particularly as they recover from complete collapse. Most collapsed dogs are totally conscious and alert, still trying to run and retrieve, but as many as 25% of affected dogs will appear stunned or disoriented during the episode.

Trait of Inheritance
EIC follows an autosomal recessive trait of inheritance.

Inheritance : AUTOSOMAL RECESSIVE trait



  Dam   Offspring
100% clear
50%  clear + 50% carriers
100% carriers
50%  clear + 50% carriers
25% clear + 25% affected + 50% carriers
50% carriers + 50% affected
100%  carriers
50% carriers + 50% affected
100% affected



Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Exercise Induced Collapse ( EIC ) and therefore it can be bred to any other dog.



Genotype: N / EIC [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop Exercise Induced Collapse ( EIC ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)



Genotype: EIC / EIC [ Homozygous mutant ]


The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop Exercise Induced Collapse ( EIC ) and will pass the mutant gene to its entire offspring

The the genetic mutation responsible for susceptibility to EIC was identified at the University of Minnesota (EE Patterson, JR Mickelson, KM Minor).

This is a mutation based test that classifies dogs as Clear, Carriers and Affected. Clear and Carrier dogs will not show signs of EIS, however carriers can pass the mutation to their offspring. The test provides reliable information to dog breeders and owners that enable them to control the spread of the mutation in the breed.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
1 - 2 weeks
£ 66.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

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