LABOKLIN (UK)|Genetic Diseases | Dogs| Factor VII Deficiency

Factor VII Deficiency

Breeds

Airedale , Alaskan Klee Kai , Beagle , Giant Schnauzer , Scottish Deerhound .

The Disease

Factor VII deficiency is a mild bleeding disorder caused by lack of factor VII (proconvertin) which plays a role in the blood clotting system. Affected dogs bruise easily and nosebleeds maybe seen. There is often prolonged bleeding after surgery or trauma and, in the cases of major surgical procedures or trauma, bleeding maybe severe.

The condition may go unnoticed for long time and discovered only when a surgery is performed or if the dog had an accident, in both cases increased bleeding will be noticed which can be difficult to control. Your vet will suspect a bleeding disorder.

Trait of Inheritance

Factor V Deficiency follows an autosomal recessive mode of inheritance.

Inheritance : AUTOSOMAL RECESSIVE trait

Sire
Dam Offspring

Clear
x
Clear
>
100% Clear

clear
x
carrier
>
50% Clear + 50% carriers

clear
x
affected
>
100% carriers

carrier
x
Clear
>
50% Clear + 50% carriers

carrier
x
carrier
>
25% clear + 25% affected + 50% carriers

carrier
x
affected
>
50% carriers + 50% affected

affected
x
Clear
>
100% carriers

affected
x
carrier
>
50% carriers + 50% affected

affected
x
affected
>
100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.
The dog will never develop Factor VII Deficiency and therefore it can be bred to any other dog.

Carrier

Genotype: N / FVII [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.
The dog will never develop Factor VII Deficiency but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: FVII / FVII [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog will develop Factor VII Deficiency and will pass the mutant gene to its entire offspring

Description

Recently, the mutation responsible for this condition has been identified by Dr Urs Giger and researchers at the University of Pennsylvania. The test is now available at LABOKLIN. Factor VII deficiency follows a recessive trait of inheritance, the test identify a dog as affected (2 copies of the abnormal gene), clear (0 copies of the abnormal gene) or carrier (1 copy of the abnormal gene). Only affected dogs with two copies of the affected gene will develop the disease. Since this is am autosomal recessive condition, carrier dogs will not develop the disease but will pass the mutation to their offspring.

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

withing 7 working days

Price

£ 49.99 (including VAT)

LABOKLIN GmbH & Co. KG

ISO / DIN 17025 Accredited Laboratory

61 Mouldsworth Ave, Manchester M20 1GG