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Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Mycobacterium Avium Complex ( MAC ) sensitivity in Miniature Schnauzer
new test: Chondrodystrophy (CDDY with IVDD Risk) and Chondrodysplasia (CDPA) in many breeds ...
new test: Lafora Disease (LAF)/ Myoclonic Epilepsy in Basset Hound, Beagle, Chihuahua and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Sensory Neuropathy in Border Collie
• Neuroaxonal Dystrophy ( NAD ) in Papillon


Coat Colour variant Siamese (Point)

Test number: 8085

Breed
Various cat breeds .
Description

Siamese and Burmese patterns

The Siamese pattern is reponsible for a phenotype representing a mild form of albinism. This temperature-sensitive mutation produces normal colour pigment only at the cooler extremities of the body, causing a mask of the face as well as darkened paws and tail. The Siamese pattern is also called mask factor or point, since normal pigmentation occurs only at the cooler points of the body.

The Burmese pattern, the mildest form of albinism, is characterized by a normal pigmentation of the extremities and a slight shading of normal body colour.

Two mutations in the gene encoding the enzyme tyrosinase which is required for melanin production are responsible for these colour variants. This gene locus is called C-locus. The wild type allele C is dominant and causes full pigmentation, the Siamese cs allele is recessive and leads to the characteristic distribution of the dark colour on ears, mask, tail and legs when in the homozygous state. The Burmese pattern also follows a recessive inheritance and leads to the coat colour Burmese brown in the homozygous state, with varying degrees of black and dark brown.

How can the different genotypes for the colours chocolate and cinnamon and the Siamese and Burmese patterns be identified ?

Recently, the mutations leading to the different coat colours have been found in the USA, thus permitting the development of a genetic test for each of the colours. After validating these tests in collaboration with several german veterinarians and cat breeders, Laboklin can now offer the tests to all interested breeders. For the coat colour chocolate, Laboklin tests the four most important gene loci, therefore ensuring a very reliable test. For the coat colour cinnamon as well as the Siamese and Burmese coat patterns, only one mutation has been published to be responsible for the corresponding colour.

How does the genetic test work and how safe is it?

Firstly, the DNA which is the genetic information of an animal is isolated from a blood or a cheek swab sample. Then the genes of interest are amplified a million-fold by PCR (polymerase chain reaction) to facilitate the following analysis. The analysis is automatically performed by a genetic analyzer and reveals the gene sequence of the region of interest.

Therefore, the mutations leading to the different coat colours can be seen directly and heterozygous carriers of these mutations can also be identified. Since the test is done mainly automatically, laboratory errors can be widely excluded.

Interpretation of the test results

The test results will be submitted separately for each coat colour, so that the genotype for each corresponding gene locus will be given.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs. Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
2 - 3 weeks
Price
Number of Coat Colour Tests on the same cat Price (including VAT)
First Colour test £ 48.00
Each additional colour test on the same cat £ 24.00

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
Coat Colour cinnamon  
Curly Coat  
Coat Colour Burmese brown  
Coat colour Variant Agouti (Tabby)  
Coat Colour DILUTION  
Coat Length  
Coat Colour Charcoal  
Coat colour amber  
Coat Colour Albino  
Dominant White / White Spotting  
Sphynx / Devon Rex  
Coat Colour: Snow  
Coat Colour: Chocolate and Cinnamon  
Colourpoint Siamese and Burmese ( Siamese , Burmese and Mink )  
Feline Coat Colours OFFER: Agouti + Burma + Chocolate + Cinnamon + Dilution + Siam  
Bengal Colours OFFER: Charcoal + Chocolate + Cinnamon + Snow + Dilution  
Russet Coat Colour  
Coat Colour chocolate  

 
 
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LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066