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HYPP (Hypercalaemic Periodic Paralysis)

Test number: 8000HGD

H

Breeds
Appaloosas , Paint Horse , Quarter Horse (Horse with quarter horse blood) .
The Disease
Hyperkalaemic Periodic Paralysis has been reported in Quarter Horses (Offsprings of the stallion Impressiveâ) and horses with Quarterhorse blood (Apaloosas and Paints). The disease is characterized by intermittent episodes of muscular fasciculations, weakness, myotonia, or involuntary recumbency. HYPP is the result of a genetic mutation in the sodium channel gene of skeletal muscles. It is inherited as an autosomal dominant trait. That means that a heterozygous carrier of the defect gene shows the same symptoms than a horse with both allels affected. The breeding of an genetically clear horse with a heterozygous carrier produces a diseased horse with a probability of 50%.
Trait of Inheritance
HYPP follows an autosomal dominant trait of inheritance.

Inheritance : AUTOSOMAL DOMINANT trait

 

Sire

  Dam   Offspring
         
Clear (N/N)
x
Clear (N/N)
>
100% Clear (N/N)
         
clear (N/N)
x
affected (N/H)
>
50%  Clear  (N/N) + 50% affected (N/H)
         
clear (N/N)
x
affected  (H/H)
>
100% affected (N/H)
         
affected (N/H)
x
Clear (N/N)
>
50%  Clear (N/N) + 50% affected (N/H)
         
affected (N/H)
x
affected (N/H)
>
25% clear (N/N) + 25% affected (H/H) + 50% affected (N/H)
         
affected (N/H)
x
affected (H/H)
>
50% affected (N/H)+ 50% affected (H/H)
         
affected  (H/H)
x
Clear (N/N)
>
100%  affected (N/H)
         
affected  H/H
x
affected (N/H)
>
50% affected (N/H)+ 50% affected  (H/H)
         
affected  (H/H)
x
affected  (H/H)
>
100% affected  (H/H)

 


Clear

Genotype: N / N [ Homozygous normal ]

The horse is noncarrier of the mutant gene.

The horse will never develop HYPP (Hypercalaemic Periodic Paralysis) and therefore it can be used in breeding.

 

Affected

Affected horses can have one of two genotypes:

Genotype: N / H [ Heterozygous affected], or

Genotype: H / H [ Homozygous affected ]

 

It is not recommended to use affected horses in breeding

The horse will develop HYPP (Hypercalaemic Periodic Paralysis) and will pass the mutant gene to its offspring
Description

This is a mutation-based gene test, which offers many advantages over other methods

The genetic defect leading to the disease has been identified. By DNA testing the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear horses, but also to identify carriers.

 
Further reading
Hyerkalemic Periodic Paralysishtml file
Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. Hair sample from mane with roots (approx 30 hairs) , Buccal swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted. .
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF

See Also:
IMM and MYH1 Myopathy ( MYHM ) *  
OLWS / LWO ( Lethal White Foal Syndrome-Frame Overo)  
H-JEB (Herlitz Junctional epidermolysis bullosa)  
HERDA (Hereditary Equine Regional Dermal Asthenia)  
PSSM (Polysaccharid Storage Myopathy)  
Cerebellar Abiotrophy (CA)  
Lavender Foal Syndrome (LFS) / Coat Colour Dilution Lethal (CCDL)  
Glycogen Branching Enzyme Deficiency (GBED)  
Equine Malignant Hypethermia (EMH)  
Warmblood Fragile Foal Syndrome (WFFS)  
Hereditary Myotonia / Congenital Myotonia  
Special Offer 1: PSSM + HERDA + GBED + HYPP (Save £54)  
Special Offer 2: PSSM + HERDA + GBED + HYPP + OLWS (Save £90.00)  
Special Offer 3: CA + LFS + SCID (Save £12)  
Connemara Pony Hoof Wall Separation Disease  
5 Panel test: PSSM + HERDA + GBED + HYPP + EMH (Save £90.00)  
FOAL IMMUNODEFICIENCY SYNDROME (FIS)  
Special Offer Quarab: PSSM + HERDA + GBED + CA + SCID  
Naked Foal Syndrome ( NFS )  
Ocular Squamous Cell Carcinoma (SCC)  
SCID (Severe Combined Immunodeficiency)  

 
 
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LABOKLIN GmbH & Co. KG
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© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066